Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Thomas J. Montine; Sarah E. Monsell; Thomas G. Beach; Eileen H. Bigio; Yunqi Bu; Nigel J. Cairns; Matthew Frosch; Jonathan Henriksen; Julia Kofler; Walter A. Kukull; Edward B. Lee; Peter T. Nelson; Aimee M. Schantz; Julie A. Schneider; Joshua A. Sonnen; John Q. Trojanowski; Harry V. Vinters; Xiao Hua Zhou; Bradley T. Hyman

doi:10.1016/j.jalz.2015.07.492

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Thomas J. Montine
, Sarah E. Monsell
, Thomas G. Beach
, Eileen H. Bigio
, Yunqi Bu
, Nigel J. Cairns
, Matthew Frosch
, Jonathan Henriksen
, Julia Kofler
, Walter A. Kukull
, Edward B. Lee
, Peter T. Nelson
, Aimee M. Schantz
, Julie A. Schneider
, Joshua A. Sonnen
, John Q. Trojanowski
, Harry V. Vinters
, Xiao Hua Zhou
, Bradley T. Hyman

Producción científica: Article › revisión exhaustiva

97 Citas (Scopus)

Resumen

Introduction Neuropathologic assessment is the current "gold standard" for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ =.88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements.

Idioma original	English
Páginas (desde-hasta)	164-169
Número de páginas	6
Publicación	Alzheimer's and Dementia
Volumen	12
N.º	2
DOI	https://doi.org/10.1016/j.jalz.2015.07.492
Estado	Published - feb 1 2016

Nota bibliográfica

Publisher Copyright:
© 2016 The Alzheimer's Association.

Financiación

This work was supported by the following grants from the National Institute on Aging , National Institutes of Health : the, National Alzheimer's Coordinating Center ( U01 AG016976 ), Alzheimer's Disease Centers ( P50 AG05133 , P50 AG05134 , P50 AG05136 , P50 AG05681 , P30 AG10161 , P30 AG10124 , P30 AG13854 , P50 AG16570 , P30 AG19610 , and P30 AG28383 ), and P01 AG03991 . We thank Dr Kathleen Montine for editorial assistance. This work was supported by the following grants from the National Institute on Aging, National Institutes of Health: the, National Alzheimer''s Coordinating Center (U01 AG016976), Alzheimer''s Disease Centers (P50 AG05133, P50 AG05134, P50 AG05136, P50 AG05681, P30 AG10161, P30 AG10124, P30 AG13854, P50 AG16570, P30 AG19610, and P30 AG28383), and P01 AG03991. We thank Dr Kathleen Montine for editorial assistance.

Financiadores	Número del financiador
Alzheimer's Disease Centers	P50 AG05133, P30 AG10124, P50 AG16570, P50 AG05134, P30 AG28383, P50 AG05136, P30 AG13854, P30 AG19610, P01 AG03991, P30 AG10161, P50 AG05681
National Alzheimer's Coordinating Center	U01 AG016976
National Institutes of Health (NIH)
National Institute on Aging	P50AG005134, P01AG003991

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2015.07.492

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Montine, T. J., Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., Lee, E. B., Nelson, P. T., Schantz, A. M., Schneider, J. A., Sonnen, J. A., Trojanowski, J. Q., Vinters, H. V., Zhou, X. H., & Hyman, B. T. (2016). Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's and Dementia, 12(2), 164-169. https://doi.org/10.1016/j.jalz.2015.07.492

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title = "Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease",

abstract = "Introduction Neuropathologic assessment is the current {"}gold standard{"} for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ =.88, 95\% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements.",

keywords = "Alzheimer's disease, Methods, Multisite, Neuropathology, Whole-slide imaging",

author = "Montine, \{Thomas J.\} and Monsell, \{Sarah E.\} and Beach, \{Thomas G.\} and Bigio, \{Eileen H.\} and Yunqi Bu and Cairns, \{Nigel J.\} and Matthew Frosch and Jonathan Henriksen and Julia Kofler and Kukull, \{Walter A.\} and Lee, \{Edward B.\} and Nelson, \{Peter T.\} and Schantz, \{Aimee M.\} and Schneider, \{Julie A.\} and Sonnen, \{Joshua A.\} and Trojanowski, \{John Q.\} and Vinters, \{Harry V.\} and Zhou, \{Xiao Hua\} and Hyman, \{Bradley T.\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Alzheimer's Association.",

year = "2016",

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doi = "10.1016/j.jalz.2015.07.492",

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Montine, TJ, Monsell, SE, Beach, TG, Bigio, EH, Bu, Y, Cairns, NJ, Frosch, M, Henriksen, J, Kofler, J, Kukull, WA, Lee, EB, Nelson, PT, Schantz, AM, Schneider, JA, Sonnen, JA, Trojanowski, JQ, Vinters, HV, Zhou, XH & Hyman, BT 2016, 'Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease', Alzheimer's and Dementia, vol. 12, n.º 2, pp. 164-169. https://doi.org/10.1016/j.jalz.2015.07.492

TY - JOUR

T1 - Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

AU - Montine, Thomas J.

AU - Monsell, Sarah E.

AU - Beach, Thomas G.

AU - Bigio, Eileen H.

AU - Bu, Yunqi

AU - Cairns, Nigel J.

AU - Frosch, Matthew

AU - Henriksen, Jonathan

AU - Kofler, Julia

AU - Kukull, Walter A.

AU - Lee, Edward B.

AU - Nelson, Peter T.

AU - Schantz, Aimee M.

AU - Schneider, Julie A.

AU - Sonnen, Joshua A.

AU - Trojanowski, John Q.

AU - Vinters, Harry V.

AU - Zhou, Xiao Hua

AU - Hyman, Bradley T.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Introduction Neuropathologic assessment is the current "gold standard" for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ =.88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements.

AB - Introduction Neuropathologic assessment is the current "gold standard" for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ =.88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements.

KW - Alzheimer's disease

KW - Methods

KW - Multisite

KW - Neuropathology

KW - Whole-slide imaging

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AN - SCOPUS:84957851029

SN - 1552-5260

VL - 12

SP - 164

EP - 169

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

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ER -

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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