Multisite microelectrode arrays for measurements of multiple neurochemicals

Multisite microelectrode arrays designed for electrochemical measures of neurochemicals in CNS tissues are presented. The arrays have platinum recording sites insulated with polyimide on a ceramic substrate. Most designs include 4 recording sites, however arrays with 5 to 8 recording sites have been fabricated. Enzyme coatings have been developed to measure glutamate, choline, lactate, and glucose. Electroactive compounds such as dopamine, norepinephrine, and O₂ can also be measured. The multiple recording sites can be exploited for interferent or noise removal and measures of multiple compounds using a single microelectrode array.