Natural Kills Cells

Roman Deniskin; Lisa Forbes Satter

doi:10.1016/B978-0-12-818731-9.00172-5

Natural Kills Cells

Roman Deniskin
, Lisa Forbes Satter

Producción científica: Chapter › revisión exhaustiva

Resumen

Natural killer (NK) cells are cytotoxic lymphocytes that function at the interface of innate and adaptive immunity. NK cells are essential for the defense against viral pathogens and are involved in tumor surveillance, atopic diseases, and many autoimmune/inflammatory disorders. In the following chapter, we provide an overview of NK cell development, activation, and NK cell effector function. We provide a comprehensive clinical overview of NK cell deficiencies including impairment of NK cell development and/or function. Overall, this chapter summarizes NK cell biology and function in both healthy and diseased conditions.

Idioma original	English
Título de la publicación alojada	Encyclopedia of Infection and Immunity
Subtítulo de la publicación alojada	Volumes 1-4
Páginas	V1-118-V1-129
Volumen	1
ISBN (versión digital)	9780323903035
DOI	https://doi.org/10.1016/B978-0-12-818731-9.00172-5
Estado	Published - ene 1 2022

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© 2022 Elsevier Inc. All rights reserved.

ODS de las Naciones Unidas

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ASJC Scopus subject areas

General Immunology and Microbiology

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10.1016/B978-0-12-818731-9.00172-5

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AB - Natural killer (NK) cells are cytotoxic lymphocytes that function at the interface of innate and adaptive immunity. NK cells are essential for the defense against viral pathogens and are involved in tumor surveillance, atopic diseases, and many autoimmune/inflammatory disorders. In the following chapter, we provide an overview of NK cell development, activation, and NK cell effector function. We provide a comprehensive clinical overview of NK cell deficiencies including impairment of NK cell development and/or function. Overall, this chapter summarizes NK cell biology and function in both healthy and diseased conditions.

KW - Cancer

KW - Cytotoxicity

KW - Immune deficiency

KW - Innate immunity

KW - Natural killer cells

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VL - 1

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BT - Encyclopedia of Infection and Immunity

ER -

Natural Kills Cells

Resumen

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ODS de las Naciones Unidas

ASJC Scopus subject areas

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