Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring

Guoqiang Yu

doi:10.1117/1.JBO.17.1.010901

Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring

Guoqiang Yu

Producción científica: Article › revisión exhaustiva

79 Citas (Scopus)

Resumen

A novel near-infrared (NIR) diffuse correlation spectroscopy (DCS) for tumor blood flow measurement is introduced in this review paper. DCS measures speckle fluctuations of NIR diffuse light in tissue, which are sensitive to the motions of red blood cells. DCS offers several attractive new features for tumor blood flow measurement such as noninvasiveness, portability, high temporal resolution, and relatively large penetration depth. DCS technology has been utilized for continuous measurement of tumor blood flow before, during, and after cancer therapies. In those pilot investigations, DCS hemodynamic measurements add important new variables into the mix for differentiation of benign from malignant tumors and for prediction of treatment outcomes. It is envisaged that with more clinical applications in large patient populations, DCS might emerge as an important method of choice for bedside management of cancer therapy, and it will certainly provide important new information about cancer physiology that may be of use in diagnosis.

Idioma original	English
Número de artículo	010901
Publicación	Journal of Biomedical Optics
Volumen	17
N.º	1
DOI	https://doi.org/10.1117/1.JBO.17.1.010901
Estado	Published - ene 2012

Nota bibliográfica

Funding Information:
The author thanks the National Institutes of Health (NIH) R01 CA149274 and National Center for Research Resources (NCRR) UL1RR033173. Most of data presented in this paper were collected from Dr. Arjun G. Yodh’s laboratory and the hospital at the University of Pennsylvania. The author also gratefully acknowledges discussions and interactions with numerous scientists in the biomedical optics community, including Arjun G. Yodh, Turgut Durduran, Chao Zhou, Ulas Sunar, Hsing-wen Wang, Xiaoman Xing, Regine Choe, Theresa M. Busch, Steven M. Hahn, Timothy C. Zhu, Jarod C. Finlay, Harry Quon, and Mahesh Kudrimoti.

Financiación

The author thanks the National Institutes of Health (NIH) R01 CA149274 and National Center for Research Resources (NCRR) UL1RR033173. Most of data presented in this paper were collected from Dr. Arjun G. Yodh’s laboratory and the hospital at the University of Pennsylvania. The author also gratefully acknowledges discussions and interactions with numerous scientists in the biomedical optics community, including Arjun G. Yodh, Turgut Durduran, Chao Zhou, Ulas Sunar, Hsing-wen Wang, Xiaoman Xing, Regine Choe, Theresa M. Busch, Steven M. Hahn, Timothy C. Zhu, Jarod C. Finlay, Harry Quon, and Mahesh Kudrimoti.

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute	R01CA149274
National Center for Research Resources	UL1RR033173

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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title = "Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring",

abstract = "A novel near-infrared (NIR) diffuse correlation spectroscopy (DCS) for tumor blood flow measurement is introduced in this review paper. DCS measures speckle fluctuations of NIR diffuse light in tissue, which are sensitive to the motions of red blood cells. DCS offers several attractive new features for tumor blood flow measurement such as noninvasiveness, portability, high temporal resolution, and relatively large penetration depth. DCS technology has been utilized for continuous measurement of tumor blood flow before, during, and after cancer therapies. In those pilot investigations, DCS hemodynamic measurements add important new variables into the mix for differentiation of benign from malignant tumors and for prediction of treatment outcomes. It is envisaged that with more clinical applications in large patient populations, DCS might emerge as an important method of choice for bedside management of cancer therapy, and it will certainly provide important new information about cancer physiology that may be of use in diagnosis.",

keywords = "Blood flow, Cancer, Correlation, Diffusion, Spectroscopy, Therapy",

author = "Guoqiang Yu",

note = "Funding Information: The author thanks the National Institutes of Health (NIH) R01 CA149274 and National Center for Research Resources (NCRR) UL1RR033173. Most of data presented in this paper were collected from Dr. Arjun G. Yodh{\textquoteright}s laboratory and the hospital at the University of Pennsylvania. The author also gratefully acknowledges discussions and interactions with numerous scientists in the biomedical optics community, including Arjun G. Yodh, Turgut Durduran, Chao Zhou, Ulas Sunar, Hsing-wen Wang, Xiaoman Xing, Regine Choe, Theresa M. Busch, Steven M. Hahn, Timothy C. Zhu, Jarod C. Finlay, Harry Quon, and Mahesh Kudrimoti.",

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KW - Blood flow

KW - Cancer

KW - Correlation

KW - Diffusion

KW - Spectroscopy

KW - Therapy

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SN - 1083-3668

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Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring

Resumen

Nota bibliográfica

Financiación

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ASJC Scopus subject areas

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