Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease

G. Ransmayr; H. Benesch; C. Nowakowski; G. Künig; H. Heinsen; P. Riederer; L. B. Hersh

doi:10.1016/0304-3940(94)90032-9

Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease

G. Ransmayr
, H. Benesch
, C. Nowakowski
, G. Künig
, H. Heinsen
, P. Riederer
, L. B. Hersh

Producción científica: Article › revisión exhaustiva

5 Citas (Scopus)

Resumen

The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four control subjects and four patients with dementia of the Alzheimer type (DAT). Neuronal counts on sections stained with silver and a polyclonal antibody to human choline acetyltransferase (ChAT) revealed an undiminished number of LVN neurons in patients with DAT. Numerous silver-stained neurofibrillary tangles (NFTs) were found in the DAT group, some also in the LVN of controls. These findings suggest that DAT affects LVN neurons, however without causing neuronal loss.

Idioma original	English
Páginas (desde-hasta)	11-14
Número de páginas	4
Publicación	Neuroscience Letters
Volumen	177
N.º	1-2
DOI	https://doi.org/10.1016/0304-3940(94)90032-9
Estado	Published - ago 15 1994

Nota bibliográfica

Funding Information:
This project was supported by a grant from the Leopold Franzens University, lnnsbruck, 1992 and in part by the NIH Grant AG05893.

Financiación

This project was supported by a grant from the Leopold Franzens University, lnnsbruck, 1992 and in part by the NIH Grant AG05893.

Financiadores	Número del financiador
Leopold Franzens University
National Institutes of Health (NIH)
National Institute on Aging	R55AG005893

ASJC Scopus subject areas

General Neuroscience

Acceder al documento

10.1016/0304-3940(94)90032-9

Otros archivos y enlaces

Citar esto

@article{2eb9fad944cc4a1f8c63c165deccf7af,

title = "Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease",

abstract = "The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four control subjects and four patients with dementia of the Alzheimer type (DAT). Neuronal counts on sections stained with silver and a polyclonal antibody to human choline acetyltransferase (ChAT) revealed an undiminished number of LVN neurons in patients with DAT. Numerous silver-stained neurofibrillary tangles (NFTs) were found in the DAT group, some also in the LVN of controls. These findings suggest that DAT affects LVN neurons, however without causing neuronal loss.",

keywords = "Choline acetyltransferase, Cholinergic neuron, Dementia of the Alzheimer type, Immunohistochemistry, Lateral vestibular nucleus, Neurofibrillary tangle",

author = "G. Ransmayr and H. Benesch and C. Nowakowski and G. K{\"u}nig and H. Heinsen and P. Riederer and Hersh, \{L. B.\}",

note = "Funding Information: This project was supported by a grant from the Leopold Franzens University, lnnsbruck, 1992 and in part by the NIH Grant AG05893.",

year = "1994",

month = aug,

day = "15",

doi = "10.1016/0304-3940(94)90032-9",

language = "English",

volume = "177",

pages = "11--14",

number = "1-2",

}

TY - JOUR

T1 - Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease

AU - Ransmayr, G.

AU - Benesch, H.

AU - Nowakowski, C.

AU - Künig, G.

AU - Heinsen, H.

AU - Riederer, P.

AU - Hersh, L. B.

N1 - Funding Information: This project was supported by a grant from the Leopold Franzens University, lnnsbruck, 1992 and in part by the NIH Grant AG05893.

PY - 1994/8/15

Y1 - 1994/8/15

N2 - The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four control subjects and four patients with dementia of the Alzheimer type (DAT). Neuronal counts on sections stained with silver and a polyclonal antibody to human choline acetyltransferase (ChAT) revealed an undiminished number of LVN neurons in patients with DAT. Numerous silver-stained neurofibrillary tangles (NFTs) were found in the DAT group, some also in the LVN of controls. These findings suggest that DAT affects LVN neurons, however without causing neuronal loss.

AB - The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four control subjects and four patients with dementia of the Alzheimer type (DAT). Neuronal counts on sections stained with silver and a polyclonal antibody to human choline acetyltransferase (ChAT) revealed an undiminished number of LVN neurons in patients with DAT. Numerous silver-stained neurofibrillary tangles (NFTs) were found in the DAT group, some also in the LVN of controls. These findings suggest that DAT affects LVN neurons, however without causing neuronal loss.

KW - Choline acetyltransferase

KW - Cholinergic neuron

KW - Dementia of the Alzheimer type

KW - Immunohistochemistry

KW - Lateral vestibular nucleus

KW - Neurofibrillary tangle

UR - https://www.scopus.com/pages/publications/0028131327

UR - https://www.scopus.com/pages/publications/0028131327#tab=citedBy

U2 - 10.1016/0304-3940(94)90032-9

DO - 10.1016/0304-3940(94)90032-9

M3 - Article

C2 - 7824159

AN - SCOPUS:0028131327

SN - 0304-3940

VL - 177

SP - 11

EP - 14

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto