Non-template functions of the viral RNA in plant RNA virus replication

Kunj B. Pathak; Judit Pogany; Peter D. Nagy

doi:10.1016/j.coviro.2011.09.011

Non-template functions of the viral RNA in plant RNA virus replication

Kunj B. Pathak
, Judit Pogany
, Peter D. Nagy

Plant Pathology

Producción científica: Review article › revisión exhaustiva

26 Citas (Scopus)

Resumen

In addition to the essential function of the viral RNA as a template during replication of positive-stranded (+)RNA viruses, the RNA also has crucial non-template functions. These functions during replication include the recruitment of the viral RNA to the site of replication and assembly of the functional viral replicase complex. The RNA recruitment elements are specifically recognized by the viral replication protein, but also affected by host factors such as elongation factor 1A or P-body proteins. The cis-elements for replicase assembly can partially overlap with RNA recruitment elements and they may provide a platform for the assembly of the replicase complex consisting of viral and host proteins. This review focuses on our current knowledge obtained with tombusviruses and other plant viruses. Altogether, understanding of the non-template functions of the viral RNA during viral replication provides new insights into virus-host interactions.

Idioma original	English
Páginas (desde-hasta)	332-338
Número de páginas	7
Publicación	Current Opinion in Virology
Volumen	1
N.º	5
DOI	https://doi.org/10.1016/j.coviro.2011.09.011
Estado	Published - nov 2011

Nota bibliográfica

Funding Information:
We thank members of our laboratory for valuable discussions on the areas of this review. We apologize to those colleagues whose work could not be included because of space restrictions. This work was supported by the National Institute of Allergy and Infectious Diseases ( NIH-NIAID AI05767001A1 ) and by the University of Kentucky , awarded to PDN and by a Philip Morris fellowship to KBP.

Financiación

We thank members of our laboratory for valuable discussions on the areas of this review. We apologize to those colleagues whose work could not be included because of space restrictions. This work was supported by the National Institute of Allergy and Infectious Diseases ( NIH-NIAID AI05767001A1 ) and by the University of Kentucky , awarded to PDN and by a Philip Morris fellowship to KBP.

Financiadores	Número del financiador
NIH-NIAID	AI05767001A1
National Institutes of Health (NIH)	F32AI005767
National Institute of Allergy and Infectious Diseases
Philips Lighting
University of Kentucky

ASJC Scopus subject areas

Virology

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N2 - In addition to the essential function of the viral RNA as a template during replication of positive-stranded (+)RNA viruses, the RNA also has crucial non-template functions. These functions during replication include the recruitment of the viral RNA to the site of replication and assembly of the functional viral replicase complex. The RNA recruitment elements are specifically recognized by the viral replication protein, but also affected by host factors such as elongation factor 1A or P-body proteins. The cis-elements for replicase assembly can partially overlap with RNA recruitment elements and they may provide a platform for the assembly of the replicase complex consisting of viral and host proteins. This review focuses on our current knowledge obtained with tombusviruses and other plant viruses. Altogether, understanding of the non-template functions of the viral RNA during viral replication provides new insights into virus-host interactions.

AB - In addition to the essential function of the viral RNA as a template during replication of positive-stranded (+)RNA viruses, the RNA also has crucial non-template functions. These functions during replication include the recruitment of the viral RNA to the site of replication and assembly of the functional viral replicase complex. The RNA recruitment elements are specifically recognized by the viral replication protein, but also affected by host factors such as elongation factor 1A or P-body proteins. The cis-elements for replicase assembly can partially overlap with RNA recruitment elements and they may provide a platform for the assembly of the replicase complex consisting of viral and host proteins. This review focuses on our current knowledge obtained with tombusviruses and other plant viruses. Altogether, understanding of the non-template functions of the viral RNA during viral replication provides new insights into virus-host interactions.

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Non-template functions of the viral RNA in plant RNA virus replication

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