Resumen
A noncontact diffuse correlation spectroscopy (DCS) probe has been developed using two separated optical paths for the source and detector. This unique design avoids the interference between the source and detector and allows large source-detector separations for deep tissue blood flow measurements. The noncontact probe has been calibrated against a contact probe in a tissue-like phantom solution and human muscle tissues; flow changes concurrently measured by the two probes are highly correlated in both phantom (R2 1/4 0.89, p < 10?5) and real-tissue (R2 1/4 0.77, p < 10?5, n 1/4 9) tests. The noncontact DCS holds promise for measuring blood flow in vulnerable (e.g., pressure ulcer) and soft (e.g., breast) tissues without distorting tissue hemodynamic properties.
| Idioma original | English |
|---|---|
| Publicación | Journal of Biomedical Optics |
| Volumen | 17 |
| N.º | 1 |
| DOI | |
| Estado | Published - ene 2012 |
Nota bibliográfica
Funding Information:The authors thank funding support from the National Institutes of Health (NIH) R01 CA149274 and NIH National Center for Research Resources (NCRR) UL1RR033173.
Financiación
The authors thank funding support from the National Institutes of Health (NIH) R01 CA149274 and NIH National Center for Research Resources (NCRR) UL1RR033173.
| Financiadores | Número del financiador |
|---|---|
| National Institutes of Health (NIH) | R01 CA149274 |
| National Center for Research Resources | UL1RR033173 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering