TY - JOUR
T1 - Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema
T2 - A Case Report
AU - Holger, Dana J.
AU - Kunz Coyne, Ashlan J.
AU - Zhao, Jing J.
AU - Sandhu, Avnish
AU - Salimnia, Hossein
AU - Rybak, Michael J.
N1 - Publisher Copyright:
© 2022 The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.
AB - We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.
KW - Acinetobacter baumannii
KW - antimicrobial resistance
KW - combination therapy
KW - pneumonia
KW - sulbactam-durlobactam
UR - http://www.scopus.com/inward/record.url?scp=85128532343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85128532343&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofac092
DO - 10.1093/ofid/ofac092
M3 - Article
AN - SCOPUS:85128532343
SN - 2328-8957
VL - 9
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 4
M1 - ofac092
ER -
