Of ticks, mice and men: Understanding the dual-host lifestyle of Lyme disease spirochaetes

Justin D. Radolf; Melissa J. Caimano; Brian Stevenson; Linden T. Hu

doi:10.1038/nrmicro2714

Of ticks, mice and men: Understanding the dual-host lifestyle of Lyme disease spirochaetes

Justin D. Radolf
, Melissa J. Caimano
, Brian Stevenson
, Linden T. Hu

Producción científica: Review article › revisión exhaustiva

605 Citas (Scopus)

Resumen

In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection. During this period, there has been an extraordinary accumulation of knowledge on the phylogenetic diversity, molecular biology, genetics and host interactions of B. burgdorferi. In this Review, we integrate this large body of information into a cohesive picture of the molecular and cellular events that transpire as Lyme disease spirochaetes transit between their arthropod and vertebrate hosts during the enzootic cycle.

Idioma original	English
Páginas (desde-hasta)	87-99
Número de páginas	13
Publicación	Nature Reviews Microbiology
Volumen	10
N.º	2
DOI	https://doi.org/10.1038/nrmicro2714
Estado	Published - feb 2012

Nota bibliográfica

Funding Information:
The authors gratefully acknowledge support from the US National Institutes of Health, National Institute for Allergy and Infectious Diseases (grants AI029735 and AI029735-20S1 to J.D.R. and M.J.C.; AI085248 to M.J.C.; AI044254 to B.S.; and AI071107, AI068799, AI082436 and AI080646 to L.T.H.). The authors also thank S. Dunham-Ems, T. Petnicki-Ocwieja, E. Troy and C. Brissette for invaluable assistance with the figures and the table, many insightful comments and careful proofreading.

Financiación

The authors gratefully acknowledge support from the US National Institutes of Health, National Institute for Allergy and Infectious Diseases (grants AI029735 and AI029735-20S1 to J.D.R. and M.J.C.; AI085248 to M.J.C.; AI044254 to B.S.; and AI071107, AI068799, AI082436 and AI080646 to L.T.H.). The authors also thank S. Dunham-Ems, T. Petnicki-Ocwieja, E. Troy and C. Brissette for invaluable assistance with the figures and the table, many insightful comments and careful proofreading.

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases	AI068799, R03AI085248, AI044254, AI029735-20S1, AI082436, AI071107, AI080646

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Microbiology
General Immunology and Microbiology
Infectious Diseases

Acceder al documento

10.1038/nrmicro2714

Otros archivos y enlaces

Link to publication in Scopus

Citar esto

@article{1d5be6ad1eb74c0ca50d806e59b16ce7,

title = "Of ticks, mice and men: Understanding the dual-host lifestyle of Lyme disease spirochaetes",

abstract = "In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection. During this period, there has been an extraordinary accumulation of knowledge on the phylogenetic diversity, molecular biology, genetics and host interactions of B. burgdorferi. In this Review, we integrate this large body of information into a cohesive picture of the molecular and cellular events that transpire as Lyme disease spirochaetes transit between their arthropod and vertebrate hosts during the enzootic cycle.",

author = "Radolf, \{Justin D.\} and Caimano, \{Melissa J.\} and Brian Stevenson and Hu, \{Linden T.\}",

note = "Funding Information: The authors gratefully acknowledge support from the US National Institutes of Health, National Institute for Allergy and Infectious Diseases (grants AI029735 and AI029735-20S1 to J.D.R. and M.J.C.; AI085248 to M.J.C.; AI044254 to B.S.; and AI071107, AI068799, AI082436 and AI080646 to L.T.H.). The authors also thank S. Dunham-Ems, T. Petnicki-Ocwieja, E. Troy and C. Brissette for invaluable assistance with the figures and the table, many insightful comments and careful proofreading.",

year = "2012",

month = feb,

doi = "10.1038/nrmicro2714",

language = "English",

volume = "10",

pages = "87--99",

number = "2",

}

TY - JOUR

T1 - Of ticks, mice and men

T2 - Understanding the dual-host lifestyle of Lyme disease spirochaetes

AU - Radolf, Justin D.

AU - Caimano, Melissa J.

AU - Stevenson, Brian

AU - Hu, Linden T.

N1 - Funding Information: The authors gratefully acknowledge support from the US National Institutes of Health, National Institute for Allergy and Infectious Diseases (grants AI029735 and AI029735-20S1 to J.D.R. and M.J.C.; AI085248 to M.J.C.; AI044254 to B.S.; and AI071107, AI068799, AI082436 and AI080646 to L.T.H.). The authors also thank S. Dunham-Ems, T. Petnicki-Ocwieja, E. Troy and C. Brissette for invaluable assistance with the figures and the table, many insightful comments and careful proofreading.

PY - 2012/2

Y1 - 2012/2

N2 - In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection. During this period, there has been an extraordinary accumulation of knowledge on the phylogenetic diversity, molecular biology, genetics and host interactions of B. burgdorferi. In this Review, we integrate this large body of information into a cohesive picture of the molecular and cellular events that transpire as Lyme disease spirochaetes transit between their arthropod and vertebrate hosts during the enzootic cycle.

AB - In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection. During this period, there has been an extraordinary accumulation of knowledge on the phylogenetic diversity, molecular biology, genetics and host interactions of B. burgdorferi. In this Review, we integrate this large body of information into a cohesive picture of the molecular and cellular events that transpire as Lyme disease spirochaetes transit between their arthropod and vertebrate hosts during the enzootic cycle.

UR - https://www.scopus.com/pages/publications/84855900042

UR - https://www.scopus.com/pages/publications/84855900042#tab=citedBy

U2 - 10.1038/nrmicro2714

DO - 10.1038/nrmicro2714

M3 - Review article

C2 - 22230951

AN - SCOPUS:84855900042

SN - 1740-1526

VL - 10

SP - 87

EP - 99

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 2

ER -

Of ticks, mice and men: Understanding the dual-host lifestyle of Lyme disease spirochaetes

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto