TY - JOUR
T1 - On the acceptor substrate of C-glycosyl-transferase UrdGT2
T2 - Three prejadomycin C-glycosides from an engineered mutant of Streptomyces globisporus 1912 ΔlndE(urdGT2)
AU - Baig, Irfan
AU - Kharel, Madan
AU - Kobylyanskyy, Anton
AU - Zhu, Lili
AU - Rebets, Yuriy
AU - Ostash, Bohdan
AU - Luzhetskyy, Andriy
AU - Bechthold, Andreas
AU - Fedorenko, Victor A.
AU - Rohr, Jürgen
PY - 2006/11/27
Y1 - 2006/11/27
N2 - (Chemical Equation Presented) The transfer of the gene urdGT2, which encodes a C-glycosyltransferase in the urdamycin pathway, into the lnd-minus mutant of the landomycin (lnd) biosynthetic pathway indicates the difference in the first glycosylation step in the urdamycin and landomycin pathways. It also reveals indirectly the acceptor substrate of UrdGT2 (see scheme) and gives evidence of greatly relaxed substrate specificity of all lnd glycosyltransferases except LndGT2.
AB - (Chemical Equation Presented) The transfer of the gene urdGT2, which encodes a C-glycosyltransferase in the urdamycin pathway, into the lnd-minus mutant of the landomycin (lnd) biosynthetic pathway indicates the difference in the first glycosylation step in the urdamycin and landomycin pathways. It also reveals indirectly the acceptor substrate of UrdGT2 (see scheme) and gives evidence of greatly relaxed substrate specificity of all lnd glycosyltransferases except LndGT2.
KW - Biosynthesis
KW - Combinatorial biosynthesis
KW - Glycosides
KW - Landomycins
KW - Polyketides
UR - https://www.scopus.com/pages/publications/33845309142
UR - https://www.scopus.com/pages/publications/33845309142#tab=citedBy
U2 - 10.1002/anie.200603176
DO - 10.1002/anie.200603176
M3 - Article
C2 - 17061307
AN - SCOPUS:33845309142
SN - 1433-7851
VL - 45
SP - 7842
EP - 7846
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 46
ER -