TY - JOUR
T1 - On the mechanism of the chromate reduction by glutathione
T2 - ESR evidence for the glutathionyl radical and an isolable Cr(V) intermediate
AU - Shi, Xianglin
AU - Dalal, N. S.
PY - 1988/10/14
Y1 - 1988/10/14
N2 - With a view of elucidating the role of glutathione (GSH) in the biochemical pathways of the chromate-exposure related carcinogenesis, we carried out electron spin resonance (ESR) spectroscopic investigations of the chromate-GSH redox reactions. The ESR measurements, employing spin-traps, provide evidence for the involvement of the glutathione (GS) radical, as well as an isolable Cr(V)-glutathione intermediate. These results indicate a new mechanism for the reduction of chromate by GSH in in vitro cellular environment and help understand the (unexpected) increase in Cr(VI)-induced DNA strand breaks at elevated GSH levels.
AB - With a view of elucidating the role of glutathione (GSH) in the biochemical pathways of the chromate-exposure related carcinogenesis, we carried out electron spin resonance (ESR) spectroscopic investigations of the chromate-GSH redox reactions. The ESR measurements, employing spin-traps, provide evidence for the involvement of the glutathione (GS) radical, as well as an isolable Cr(V)-glutathione intermediate. These results indicate a new mechanism for the reduction of chromate by GSH in in vitro cellular environment and help understand the (unexpected) increase in Cr(VI)-induced DNA strand breaks at elevated GSH levels.
UR - https://www.scopus.com/pages/publications/0023811191
UR - https://www.scopus.com/pages/publications/0023811191#tab=citedBy
U2 - 10.1016/S0006-291X(88)80815-5
DO - 10.1016/S0006-291X(88)80815-5
M3 - Article
C2 - 2845969
AN - SCOPUS:0023811191
SN - 0006-291X
VL - 156
SP - 137
EP - 142
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -