Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

Weijie Guo; Binhua P. Zhou

doi:10.1016/j.gendis.2019.10.005

Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

Weijie Guo
, Binhua P. Zhou

Producción científica: Comment/debate

4 Citas (Scopus)

Resumen

Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.

Idioma original	English
Páginas (desde-hasta)	333-334
Número de páginas	2
Publicación	Genes and Diseases
Volumen	6
N.º	4
DOI	https://doi.org/10.1016/j.gendis.2019.10.005
Estado	Published - dic 2019

Nota bibliográfica

Publisher Copyright:
© 2019 Chongqing Medical University

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics(clinical)
Cell Biology

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10.1016/j.gendis.2019.10.005

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title = "Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer",

abstract = "Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.",

author = "Weijie Guo and Zhou, \{Binhua P.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Chongqing Medical University",

year = "2019",

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doi = "10.1016/j.gendis.2019.10.005",

language = "English",

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TY - JOUR

T1 - Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

AU - Guo, Weijie

AU - Zhou, Binhua P.

PY - 2019/12

Y1 - 2019/12

N2 - Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.

AB - Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.

UR - https://www.scopus.com/pages/publications/85074427513

UR - https://www.scopus.com/pages/publications/85074427513#tab=citedBy

U2 - 10.1016/j.gendis.2019.10.005

DO - 10.1016/j.gendis.2019.10.005

M3 - Comment/debate

AN - SCOPUS:85074427513

SN - 2352-4820

VL - 6

SP - 333

EP - 334

JO - Genes and Diseases

JF - Genes and Diseases

IS - 4

ER -

Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

Resumen

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ODS de las Naciones Unidas

ASJC Scopus subject areas

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