One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis

Guojun Wang; Jing Chen; Haining Zhu; Jürgen Rohr

doi:10.1021/acs.orglett.6b03708

One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis

Guojun Wang, Jing Chen, Haining Zhu, Jürgen Rohr

Producción científica: Article › revisión exhaustiva

13 Citas (Scopus)

Resumen

Early acting cyclases play critical roles in programming the polyketide biosynthesis toward certain, distinguished scaffolds. Starting from acetyl-CoA and malonyl-CoA, a one-pot enzymatic total synthesis of an anthracyclinone scaffold, presteffimycinone, was achieved by mixing polyketide synthase (PKS) and early post-PKS enzymes from the biosynthetic pathways of three different types of type II-PKS driven anticancer antibiotics, namely, the mithramycin (aureolic acid-type), gilvocarcin (rearranged angucycline-type), and steffimycin (anthracycline) pathways.

Idioma original	English
Páginas (desde-hasta)	540-543
Número de páginas	4
Publicación	Organic Letters
Volumen	19
N.º	3
DOI	https://doi.org/10.1021/acs.orglett.6b03708
Estado	Published - feb 3 2017

Nota bibliográfica

Publisher Copyright:
© 2017 American Chemical Society.

Financiación

This work was supported by NIH grants CA 091901 and GM 105977 to J.R., and the Start-Up package provided by Florida Atlantic University Harbor Branch Oceanographic Institute Foundation to G.W. We thank Dr. Yi Tang, UCLA, for providing us the construct for MatB-expression.

Financiadores	Número del financiador
Florida Atlantic University Harbor Branch Oceanographic Institute Foundation
National Institutes of Health (NIH)	GM 105977, CA 091901
National Childhood Cancer Registry – National Cancer Institute	R21CA209189
University of California, Los Angeles

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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AU - Rohr, Jürgen

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One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis

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