Ontogenetic changes in dopaminergic pre and postsynaptic elements in rat brain: Effects of quinpirole and sulpiride

The effects of quinpirole and sulpiride on dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and accumulation of dihydroxyphenylalanine (DOPA) after inhibition of DOPA decarboxylase were determined for the striatum and tegmentum of 11- and 17-day-old rat pups. In both 11- and 17-day-olds, sulpiride enhanced striatal DOPAC and DOPA accumulation; whereas, quinpirole decreased DOPAC levels and increased DA levels. In the tegmentum, sulpiride enhanced DOPA accumulation in the 11-day-olds only. ³H-spiroperidol binding sites were also measured in the striatum, nucleus accumbens, tegmentum, medial frontal cortex, and the hippocampo-entorhinal area of 11- and 17-day-old pups. Age-dependent increases in binding site density were found in the striatum and nucleus accumbens.