Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Hollie S. Skaggs; Brook A. Saunders; Rachel W. Miller; Scott T. Goodrich; Monica S. King; Kimberly D. Kimbler; Adam J. Branscum; Eric T. Fung; Paul D. Depriest; John R. Van Nagell; Frederick R. Ueland; Andre T. Baron

doi:10.3109/07357907.2013.802799

Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Hollie S. Skaggs, Brook A. Saunders, Rachel W. Miller, Scott T. Goodrich, Monica S. King, Kimberly D. Kimbler, Adam J. Branscum, Eric T. Fung, Paul D. Depriest, John R. Van Nagell, Frederick R. Ueland, Andre T. Baron

Producción científica: Article › revisión exhaustiva

2 Citas (Scopus)

Resumen

SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

Idioma original	English
Páginas (desde-hasta)	433-453
Número de páginas	21
Publicación	Cancer Investigation
Volumen	31
N.º	7
DOI	https://doi.org/10.3109/07357907.2013.802799
Estado	Published - ago 2013

Nota bibliográfica

Funding Information:
This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.

Financiación

This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.

Financiadores	Número del financiador
Division of Gynecologic Oncology
Ladies for Life Foundation
Vermillion Inc.
University of Kentucky

ASJC Scopus subject areas

Oncology
Cancer Research

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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Skaggs, H. S., Saunders, B. A., Miller, R. W., Goodrich, S. T., King, M. S., Kimbler, K. D., Branscum, A. J., Fung, E. T., Depriest, P. D., Van Nagell, J. R., Ueland, F. R., & Baron, A. T. (2013). Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms. Cancer Investigation, 31(7), 433-453. https://doi.org/10.3109/07357907.2013.802799

@article{f832adbbc72e4610b6a7f66211b3ec2c,

title = "Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms",

abstract = "SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6\% and 63.6\% sensitivity for early stage disease, respectively, at 95\% specificity and with 74.8\% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.",

keywords = "Cancer Biomarkers, Detection/Diagnosis, Ovarian Cancer, Protein Profiling, Tumor Cell Biology",

author = "Skaggs, \{Hollie S.\} and Saunders, \{Brook A.\} and Miller, \{Rachel W.\} and Goodrich, \{Scott T.\} and King, \{Monica S.\} and Kimbler, \{Kimberly D.\} and Branscum, \{Adam J.\} and Fung, \{Eric T.\} and Depriest, \{Paul D.\} and \{Van Nagell\}, \{John R.\} and Ueland, \{Frederick R.\} and Baron, \{Andre T.\}",

note = "Funding Information: This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip{\textcopyright}R arrays and reagents, and access to a ProteinChip{\textcopyright}R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.",

year = "2013",

month = aug,

doi = "10.3109/07357907.2013.802799",

language = "English",

volume = "31",

pages = "433--453",

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AU - Skaggs, Hollie S.

AU - Saunders, Brook A.

AU - Miller, Rachel W.

AU - Goodrich, Scott T.

AU - King, Monica S.

AU - Kimbler, Kimberly D.

AU - Branscum, Adam J.

AU - Fung, Eric T.

AU - Depriest, Paul D.

AU - Van Nagell, John R.

AU - Ueland, Frederick R.

AU - Baron, Andre T.

N1 - Funding Information: This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.

PY - 2013/8

Y1 - 2013/8

N2 - SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

AB - SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

KW - Cancer Biomarkers

KW - Detection/Diagnosis

KW - Ovarian Cancer

KW - Protein Profiling

KW - Tumor Cell Biology

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Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

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