Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Hollie S. Skaggs; Brook A. Saunders; Rachel W. Miller; Scott T. Goodrich; Monica S. King; Kimberly D. Kimbler; Adam J. Branscum; Eric T. Fung; Paul D. Depriest; John R. Van Nagell; Frederick R. Ueland; Andre T. Baron

doi:10.3109/07357907.2013.802799

Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Hollie S. Skaggs
, Brook A. Saunders
, Rachel W. Miller
, Scott T. Goodrich
, Monica S. King
, Kimberly D. Kimbler
, Adam J. Branscum
, Eric T. Fung
, Paul D. Depriest
, John R. Van Nagell
, Frederick R. Ueland
, Andre T. Baron

Producción científica: Article › revisión exhaustiva

2 Citas (Scopus)

Resumen

SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

Idioma original	English
Páginas (desde-hasta)	433-453
Número de páginas	21
Publicación	Cancer Investigation
Volumen	31
N.º	7
DOI	https://doi.org/10.3109/07357907.2013.802799
Estado	Published - ago 2013

Nota bibliográfica

Funding Information:
This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.

Financiación

This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.

Financiadores
Division of Gynecologic Oncology
Ladies for Life Foundation
Vermillion Inc.
University of Kentucky

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3109/07357907.2013.802799

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Skaggs, H. S., Saunders, B. A., Miller, R. W., Goodrich, S. T., King, M. S., Kimbler, K. D., Branscum, A. J., Fung, E. T., Depriest, P. D., Van Nagell, J. R., Ueland, F. R., & Baron, A. T. (2013). Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms. Cancer Investigation, 31(7), 433-453. https://doi.org/10.3109/07357907.2013.802799

@article{f832adbbc72e4610b6a7f66211b3ec2c,

title = "Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms",

abstract = "SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6\% and 63.6\% sensitivity for early stage disease, respectively, at 95\% specificity and with 74.8\% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.",

keywords = "Cancer Biomarkers, Detection/Diagnosis, Ovarian Cancer, Protein Profiling, Tumor Cell Biology",

author = "Skaggs, \{Hollie S.\} and Saunders, \{Brook A.\} and Miller, \{Rachel W.\} and Goodrich, \{Scott T.\} and King, \{Monica S.\} and Kimbler, \{Kimberly D.\} and Branscum, \{Adam J.\} and Fung, \{Eric T.\} and Depriest, \{Paul D.\} and \{Van Nagell\}, \{John R.\} and Ueland, \{Frederick R.\} and Baron, \{Andre T.\}",

note = "Funding Information: This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip{\textcopyright}R arrays and reagents, and access to a ProteinChip{\textcopyright}R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.",

year = "2013",

month = aug,

doi = "10.3109/07357907.2013.802799",

language = "English",

volume = "31",

pages = "433--453",

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T1 - Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

AU - Skaggs, Hollie S.

AU - Saunders, Brook A.

AU - Miller, Rachel W.

AU - Goodrich, Scott T.

AU - King, Monica S.

AU - Kimbler, Kimberly D.

AU - Branscum, Adam J.

AU - Fung, Eric T.

AU - Depriest, Paul D.

AU - Van Nagell, John R.

AU - Ueland, Frederick R.

AU - Baron, Andre T.

N1 - Funding Information: This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.

PY - 2013/8

Y1 - 2013/8

N2 - SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

AB - SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

KW - Cancer Biomarkers

KW - Detection/Diagnosis

KW - Ovarian Cancer

KW - Protein Profiling

KW - Tumor Cell Biology

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UR - https://www.scopus.com/pages/publications/84881276623#tab=citedBy

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DO - 10.3109/07357907.2013.802799

M3 - Article

C2 - 23915068

AN - SCOPUS:84881276623

SN - 0735-7907

VL - 31

SP - 433

EP - 453

JO - Cancer Investigation

JF - Cancer Investigation

IS - 7

ER -

Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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