TY - JOUR
T1 - Partial Synthesis of (20R,22R)-20,22-Dihydroxycholesterol
AU - Kyler, Keith S.
AU - Watt, David S.
PY - 1981/12
Y1 - 1981/12
N2 - A new procedure for assembling the cholestane side chain from 20-oxopregnanes involved the sequential construction of the C-20,22 and C-24,25 bonds via the sequential α,γ-dialkylation of 1-(phenylthio)-1-(trimethylsilyl)-2-propene. A stereoselective, partial synthesis of (20R,22R)-20,22-dihydroxycholesterol served to test the validity of this approach.
AB - A new procedure for assembling the cholestane side chain from 20-oxopregnanes involved the sequential construction of the C-20,22 and C-24,25 bonds via the sequential α,γ-dialkylation of 1-(phenylthio)-1-(trimethylsilyl)-2-propene. A stereoselective, partial synthesis of (20R,22R)-20,22-dihydroxycholesterol served to test the validity of this approach.
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U2 - 10.1021/jo00338a024
DO - 10.1021/jo00338a024
M3 - Article
AN - SCOPUS:0019769656
SN - 0022-3263
VL - 46
SP - 5182
EP - 5188
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 25
ER -