PDCD4

Hsin Sheng Yang; Qing Wang; Magdalena M. Bajer; Tobias Schmid

doi:10.1007/978-94-017-9078-9_6

PDCD4

Hsin Sheng Yang, Qing Wang, Magdalena M. Bajer, Tobias Schmid

Producción científica: Chapter › revisión exhaustiva

3 Citas (Scopus)

Resumen

PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD4 is the inhibition of translation through binding to eIF4A helicase. In this review, we will focus on recent advances in understanding the mechanism of inhibiting translation and tumorigenesis by PDCD4, the regulation of PDCD4 expression and the potential application of PDCD4 as a target for cancer diagnostics and therapeutics.

Idioma original	English
Título de la publicación alojada	Translation and Its Regulation in Cancer Biology and Medicine
Páginas	135-161
Número de páginas	27
ISBN (versión digital)	9789401790789
DOI	https://doi.org/10.1007/978-94-017-9078-9_6
Estado	Published - mar 1 2014

Nota bibliográfica

Publisher Copyright:
© 2014 Springer Science+Business Media Dordrecht. All rights reserved.

ASJC Scopus subject areas

General Medicine

ODS de las Naciones Unidas

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abstract = "PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD4 is the inhibition of translation through binding to eIF4A helicase. In this review, we will focus on recent advances in understanding the mechanism of inhibiting translation and tumorigenesis by PDCD4, the regulation of PDCD4 expression and the potential application of PDCD4 as a target for cancer diagnostics and therapeutics.",

keywords = "Cancer, Cell signaling, PDCD4, RNA helicase, S6 kinase (S6K), Translation initiation, Tumor suppressor, eIF4A, mTOR pathway, miR-21",

author = "Yang, \{Hsin Sheng\} and Qing Wang and Bajer, \{Magdalena M.\} and Tobias Schmid",

year = "2014",

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doi = "10.1007/978-94-017-9078-9\_6",

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T1 - PDCD4

AU - Yang, Hsin Sheng

AU - Wang, Qing

AU - Bajer, Magdalena M.

AU - Schmid, Tobias

PY - 2014/3/1

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N2 - PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD4 is the inhibition of translation through binding to eIF4A helicase. In this review, we will focus on recent advances in understanding the mechanism of inhibiting translation and tumorigenesis by PDCD4, the regulation of PDCD4 expression and the potential application of PDCD4 as a target for cancer diagnostics and therapeutics.

AB - PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD4 is the inhibition of translation through binding to eIF4A helicase. In this review, we will focus on recent advances in understanding the mechanism of inhibiting translation and tumorigenesis by PDCD4, the regulation of PDCD4 expression and the potential application of PDCD4 as a target for cancer diagnostics and therapeutics.

KW - Cancer

KW - Cell signaling

KW - PDCD4

KW - RNA helicase

KW - S6 kinase (S6K)

KW - Translation initiation

KW - Tumor suppressor

KW - eIF4A

KW - mTOR pathway

KW - miR-21

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DO - 10.1007/978-94-017-9078-9_6

M3 - Chapter

AN - SCOPUS:84930902508

SN - 9401790779

SN - 9789401790772

SP - 135

EP - 161

BT - Translation and Its Regulation in Cancer Biology and Medicine

ER -

PDCD4

Resumen

Nota bibliográfica

ASJC Scopus subject areas

ODS de las Naciones Unidas

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