Personality mediation of genetic effects on attention-deficit/hyperactivity disorder

Michelle M. Martel; Molly Nikolas; Katherine Jernigan; Karen Friderici; Joel T. Nigg

doi:10.1007/s10802-010-9392-3

Personality mediation of genetic effects on attention-deficit/hyperactivity disorder

Michelle M. Martel
, Molly Nikolas
, Katherine Jernigan
, Karen Friderici
, Joel T. Nigg

Psychology

Producción científica: Article › revisión exhaustiva

25 Citas (Scopus)

Resumen

Personality traits may be viable candidates for mediators of the relationship between genetic risk and ADHD. Participants were 578 children (331 boys; 320 children with ADHD) between the ages of six and 18. Parents and teachers completed a comprehensive, multistagediagnostic procedure to assess ADHD and comorbid disorders. Mother completed the California Q-Sort to assess child Big Five personality traits. Children provided buccal samples of DNA which were assayed for selected markers on DRD4, DAT1, and ADRA2A. An additive genetic risk composite was associated with ADHD symptoms and maladaptive personality traits; maladaptive personality traits were associated with ADHD symptoms. Low conscientiousness and high neuroticism partially mediated the relationship between genetic risk and ADHD symptoms. Mediation effects for conscientiousness were specific to inattentive symptoms; effects for neuroticism generalized to all disruptive behaviors. High neuroticism and low conscientiousness may be useful as early markers for children at risk for ADHD.

Idioma original	English
Páginas (desde-hasta)	633-643
Número de páginas	11
Publicación	Journal of Abnormal Child Psychology
Volumen	38
N.º	5
DOI	https://doi.org/10.1007/s10802-010-9392-3
Estado	Published - jul 2010

Nota bibliográfica

Funding Information:
This research was supported by NIH National Institute of Mental Health Grant R01-MH63146, MH59105, and MH70542 to Karen Friderici and Joel Nigg. We are indebted to the families and staff who made this study possible.

Financiación

This research was supported by NIH National Institute of Mental Health Grant R01-MH63146, MH59105, and MH70542 to Karen Friderici and Joel Nigg. We are indebted to the families and staff who made this study possible.

Financiadores	Número del financiador
National Institute of Mental Health	R01-MH63146, MH59105, MH70542, R01MH070004

ODS de las Naciones Unidas

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Good health and well being

ASJC Scopus subject areas

Developmental and Educational Psychology
Psychiatry and Mental health

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10.1007/s10802-010-9392-3

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abstract = "Personality traits may be viable candidates for mediators of the relationship between genetic risk and ADHD. Participants were 578 children (331 boys; 320 children with ADHD) between the ages of six and 18. Parents and teachers completed a comprehensive, multistagediagnostic procedure to assess ADHD and comorbid disorders. Mother completed the California Q-Sort to assess child Big Five personality traits. Children provided buccal samples of DNA which were assayed for selected markers on DRD4, DAT1, and ADRA2A. An additive genetic risk composite was associated with ADHD symptoms and maladaptive personality traits; maladaptive personality traits were associated with ADHD symptoms. Low conscientiousness and high neuroticism partially mediated the relationship between genetic risk and ADHD symptoms. Mediation effects for conscientiousness were specific to inattentive symptoms; effects for neuroticism generalized to all disruptive behaviors. High neuroticism and low conscientiousness may be useful as early markers for children at risk for ADHD.",

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AU - Friderici, Karen

AU - Nigg, Joel T.

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KW - Disruptive behaviors

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Personality mediation of genetic effects on attention-deficit/hyperactivity disorder

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

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