Phospholipase D structure and regulation

Michael A. Frohman; Andrew J. Morris

doi:10.1016/S0009-3084(99)00025-0

Phospholipase D structure and regulation

Michael A. Frohman
, Andrew J. Morris

Internal Medicine

Producción científica: Article › revisión exhaustiva

107 Citas (Scopus)

Resumen

The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Idioma original	English
Páginas (desde-hasta)	127-140
Número de páginas	14
Publicación	Chemistry and Physics of Lipids
Volumen	98
N.º	1-2
DOI	https://doi.org/10.1016/S0009-3084(99)00025-0
Estado	Published - abr 1999

Nota bibliográfica

Funding Information:
The authors thank laboratory members for critical reading of the manuscript. This work was supported by grants from the NIH to AIM (GM50388) and MAF (GM54813).

Financiación

The authors thank laboratory members for critical reading of the manuscript. This work was supported by grants from the NIH to AIM (GM50388) and MAF (GM54813).

Financiadores	Número del financiador
National Institutes of Health (NIH)	GM54813
National Institute of General Medical Sciences	R01GM050388

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Cell Biology

Acceder al documento

10.1016/S0009-3084(99)00025-0

Otros archivos y enlaces

Citar esto

@article{19396a4755f141ce92d560da4ca83d3e,

title = "Phospholipase D structure and regulation",

abstract = "The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "ARF, PLD1, PLD2, Phospholipase D, Protein kinase C, Rho",

author = "Frohman, \{Michael A.\} and Morris, \{Andrew J.\}",

note = "Funding Information: The authors thank laboratory members for critical reading of the manuscript. This work was supported by grants from the NIH to AIM (GM50388) and MAF (GM54813).",

year = "1999",

month = apr,

doi = "10.1016/S0009-3084(99)00025-0",

language = "English",

volume = "98",

pages = "127--140",

number = "1-2",

}

TY - JOUR

T1 - Phospholipase D structure and regulation

AU - Frohman, Michael A.

AU - Morris, Andrew J.

N1 - Funding Information: The authors thank laboratory members for critical reading of the manuscript. This work was supported by grants from the NIH to AIM (GM50388) and MAF (GM54813).

PY - 1999/4

Y1 - 1999/4

N2 - The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - ARF

KW - PLD1

KW - PLD2

KW - Phospholipase D

KW - Protein kinase C

KW - Rho

UR - https://www.scopus.com/pages/publications/0033020809

UR - https://www.scopus.com/pages/publications/0033020809#tab=citedBy

U2 - 10.1016/S0009-3084(99)00025-0

DO - 10.1016/S0009-3084(99)00025-0

M3 - Article

C2 - 10358935

AN - SCOPUS:0033020809

SN - 0009-3084

VL - 98

SP - 127

EP - 140

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

IS - 1-2

ER -

Phospholipase D structure and regulation

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto