Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Elisa Fabbrini; Courtney Tiemann Luecking; Latisha Love-Gregory; Adewole L. Okunade; Mihoko Yoshino; Gemma Fraterrigo; Bruce W. Patterson; Samuel Klein

doi:10.1053/j.gastro.2015.09.003

Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Elisa Fabbrini
, Courtney Tiemann Luecking
, Latisha Love-Gregory
, Adewole L. Okunade
, Mihoko Yoshino
, Gemma Fraterrigo
, Bruce W. Patterson
, Samuel Klein

Producción científica: Article › revisión exhaustiva

39 Citas (Scopus)

Resumen

Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.

Idioma original	English
Páginas (desde-hasta)	79-81.e2
Publicación	Gastroenterology
Volumen	150
N.º	1
DOI	https://doi.org/10.1053/j.gastro.2015.09.003
Estado	Published - ene 1 2016

Nota bibliográfica

Publisher Copyright:
© 2016 AGA Institute.

Financiación

The authors thank Emily Lake for assistance in recruiting the study subjects, Freida Custodio, and Jennifer Shew for technical assistance, Melisa Moore, Kathryn Gratza and the staff of the Clinical Research Unit for help in performing the studies, and the study subjects for their participation. Dr. Samuel Klein is the guarantor of this work, had full access to all the data, and takes full responsibility for the integrity of data and the accuracy of data analysis. This study was supported by National Institutes of Health grants UL1 RR024992 (Clinical Translational Science Award), DK 56341 (Nutrition and Obesity Research Center), DK 20579 (Diabetes Research Center), DK 37948, a grant from the Longer Life Foundation, and support from the Kilo Foundation.

Financiadores	Número del financiador
Kilo Foundation
National Institutes of Health (NIH)	DK 56341, DK 37948, P60DK020579
National Center for Research Resources	UL1RR024992
Longer Life Foundation

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Hepatology
Gastroenterology

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title = "Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity",

abstract = "Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.",

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AU - Fabbrini, Elisa

AU - Tiemann Luecking, Courtney

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AU - Okunade, Adewole L.

AU - Yoshino, Mihoko

AU - Fraterrigo, Gemma

AU - Patterson, Bruce W.

AU - Klein, Samuel

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N2 - Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.

AB - Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.

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Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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