Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

G. Yu; T. Durduran; C. Zhou; M. Putt; A. G. Yodh; T. M. Busch

Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

G. Yu
, T. Durduran
, C. Zhou
, M. Putt
, A. G. Yodh
, T. M. Busch

Producción científica: Conference contribution › revisión exhaustiva

Resumen

A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.

Idioma original	English
Título de la publicación alojada	Biomedical Topical Meeting, BIOMED 2004
ISBN (versión digital)	1557527695
Estado	Published - 2004
Evento	Biomedical Topical Meeting, BIOMED 2004 - Miami Beach, United States Duración: abr 14 2004 → abr 17 2004

Serie de la publicación

Nombre	Optics InfoBase Conference Papers
ISSN (versión digital)	2162-2701

Conference

Conference	Biomedical Topical Meeting, BIOMED 2004
País/Territorio	United States
Ciudad	Miami Beach
Período	4/14/04 → 4/17/04

Nota bibliográfica

Publisher Copyright:
© 2004 Optical Society of America

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

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title = "Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors",

abstract = "A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.",

author = "G. Yu and T. Durduran and C. Zhou and M. Putt and Yodh, \{A. G.\} and Busch, \{T. M.\}",

note = "Publisher Copyright: {\textcopyright} 2004 Optical Society of America; Biomedical Topical Meeting, BIOMED 2004 ; Conference date: 14-04-2004 Through 17-04-2004",

year = "2004",

language = "English",

series = "Optics InfoBase Conference Papers",

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TY - GEN

T1 - Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

AU - Yu, G.

AU - Durduran, T.

AU - Zhou, C.

AU - Putt, M.

AU - Yodh, A. G.

AU - Busch, T. M.

PY - 2004

Y1 - 2004

N2 - A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.

AB - A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.

UR - https://www.scopus.com/pages/publications/85134596310

UR - https://www.scopus.com/pages/publications/85134596310#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:85134596310

T3 - Optics InfoBase Conference Papers

BT - Biomedical Topical Meeting, BIOMED 2004

T2 - Biomedical Topical Meeting, BIOMED 2004

Y2 - 14 April 2004 through 17 April 2004

ER -

Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

Resumen

Serie de la publicación

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