Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice

Liu Li; Jiong Ding; Charles Marshall; Junying Gao; Gang Hu; Ming Xiao

doi:10.1016/j.bbr.2010.10.032

Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice

Liu Li
, Jiong Ding
, Charles Marshall
, Junying Gao
, Gang Hu
, Ming Xiao

Physical Therapy

Producción científica: Article › revisión exhaustiva

13 Citas (Scopus)

Resumen

There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of d-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.

Idioma original	English
Páginas (desde-hasta)	244-247
Número de páginas	4
Publicación	Behavioural Brain Research
Volumen	217
N.º	1
DOI	https://doi.org/10.1016/j.bbr.2010.10.032
Estado	Published - feb 2 2011

Nota bibliográfica

Funding Information:
This work was supported by the grants from National Natural Science Foundation of China (Nos. 30971020 and 30973517 ) and Natural Science Foundation of Jiangsu Educational Department ( 09KJA310003 ).

Financiación

This work was supported by the grants from National Natural Science Foundation of China (Nos. 30971020 and 30973517 ) and Natural Science Foundation of Jiangsu Educational Department ( 09KJA310003 ).

Financiadores	Número del financiador
Natural Science Foundation of Jiangsu Educational Department	09KJA310003
National Natural Science Foundation of China (NSFC)	30971020, 30973517

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2010.10.032

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title = "Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice",

abstract = "There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of d-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.",

keywords = "Alzheimer's disease, D-galactose, Mice, Morris water maze, Spatial learning and memory",

author = "Liu Li and Jiong Ding and Charles Marshall and Junying Gao and Gang Hu and Ming Xiao",

note = "Funding Information: This work was supported by the grants from National Natural Science Foundation of China (Nos. 30971020 and 30973517 ) and Natural Science Foundation of Jiangsu Educational Department ( 09KJA310003 ).",

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doi = "10.1016/j.bbr.2010.10.032",

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AU - Li, Liu

AU - Ding, Jiong

AU - Marshall, Charles

AU - Gao, Junying

AU - Hu, Gang

AU - Xiao, Ming

N1 - Funding Information: This work was supported by the grants from National Natural Science Foundation of China (Nos. 30971020 and 30973517 ) and Natural Science Foundation of Jiangsu Educational Department ( 09KJA310003 ).

PY - 2011/2/2

Y1 - 2011/2/2

N2 - There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of d-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.

AB - There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of d-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.

KW - Alzheimer's disease

KW - D-galactose

KW - Mice

KW - Morris water maze

KW - Spatial learning and memory

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SN - 0166-4328

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JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 1

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Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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