Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk

Derek Forster; Nan Lin; Justin Levens; Rachael Stone; Scott Berry; Eric Durbin; C. Darrell Jennings; Robert DiPaola; Jill M. Kolesar

doi:10.1016/j.ajic.2021.04.005

Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk

Derek Forster
, Nan Lin
, Justin Levens
, Rachael Stone
, Scott Berry
, Eric Durbin
, C. Darrell Jennings
, Robert DiPaola
, Jill M. Kolesar

Producción científica: Article › revisión exhaustiva

Resumen

Background: The purpose of this study was to assess the occupational SARS-CoV-2 infection risk among health care workers (HCW) at University of Kentucky HealthCare (UKHC) by evaluating the prevalence of SARS-CoV-2 antibodies. Methods: This is a prospective cohort study of HCW at UKHC. SARS-CoV-2 IgG antibody seropositivity was measured in a CLIA-certified laboratory utilizing the Abbott Architect SARS-CoV-2 IgG antibody assay. Demographics and work type were self-reported by study participants via an emailed survey. Results: The overall antibody positivity rate of HCW was 1.55% (5/322; 95% confidence interval: 0.65%-3.71%) at cohort entry. There were no differences in antibody positivity between those that worked directly with SARS-CoV-2 infected patients and those that did not. The antibody rate of positivity of patients during the same time period was similar, 1.8% (9/499; 95% confidence interval 0.94%-3.45%). Conclusions: Antibody positivity was low and similar between HCW and patients tested during a similar time period. HCW positivity rates did not appear to be impacted by caring for known SARS-CoV-2 infected patients suggesting that appropriate use of personal protective equipment is effective in protecting individuals from transmission.

Idioma original	English
Páginas (desde-hasta)	1158-1161
Número de páginas	4
Publicación	American Journal of Infection Control
Volumen	49
N.º	9
DOI	https://doi.org/10.1016/j.ajic.2021.04.005
Estado	Published - sept 2021

Nota bibliográfica

Publisher Copyright:
© 2021 Association for Professionals in Infection Control and Epidemiology, Inc.

Financiación

The study investigators gratefully acknowledge the UKHC health care workers who made this study possible, study staff, Justin Levens who managed the data and Leslie Ehrmantraut, who coordinated between the study team and Employee Health. The authors also acknowledge the UK Screening Testing and Tracing to Accelerate Restart and Transition (START) team for helpful discussion and critical review of the manuscript, the START team includes; Robert DiPaola, MD, Donna K. Arnett, PhD, Susanne Arnold, MD, Jay Blanton, Richard Chapman, Becky Dutch, PhD, Derek Forster, MD, Tyler Gayheart, PhD, Lauren Greathouse, Hanine El Haddad, MD, Cliff Iler, JD, C. Darrel Jennings, MD, Jill Kolesar, PharmD, Ian McClure, JD, Erin McMahon, JD, Brian Nichols, Lance Poston, PhD, Evan Ramsay, Frank Romanelli, PharmD, Jennifer Rose, Mathew Sanger, Colleen Swartz, DNP, Heidi Weiss, PhD, Pamela Woods. Conflicts of interest: None: RS, DF, RD, CJ, NL, ED. Dr Berry reports personal fees and other from Salus Discovery, LLC, outside the submitted work. Dr Kolesar reports other from Helix Diagnostic, grants and other from ArtemiLife, outside the submitted work; In addition, Dr Kolesar has a patent Copywrite pending.

Financiadores
Helix Diagnostic

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Epidemiology
Health Policy
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.ajic.2021.04.005

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Forster, D., Lin, N., Levens, J., Stone, R., Berry, S., Durbin, E., Jennings, C. D., DiPaola, R., & Kolesar, J. M. (2021). Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk. American Journal of Infection Control, 49(9), 1158-1161. https://doi.org/10.1016/j.ajic.2021.04.005

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title = "Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk",

abstract = "Background: The purpose of this study was to assess the occupational SARS-CoV-2 infection risk among health care workers (HCW) at University of Kentucky HealthCare (UKHC) by evaluating the prevalence of SARS-CoV-2 antibodies. Methods: This is a prospective cohort study of HCW at UKHC. SARS-CoV-2 IgG antibody seropositivity was measured in a CLIA-certified laboratory utilizing the Abbott Architect SARS-CoV-2 IgG antibody assay. Demographics and work type were self-reported by study participants via an emailed survey. Results: The overall antibody positivity rate of HCW was 1.55\% (5/322; 95\% confidence interval: 0.65\%-3.71\%) at cohort entry. There were no differences in antibody positivity between those that worked directly with SARS-CoV-2 infected patients and those that did not. The antibody rate of positivity of patients during the same time period was similar, 1.8\% (9/499; 95\% confidence interval 0.94\%-3.45\%). Conclusions: Antibody positivity was low and similar between HCW and patients tested during a similar time period. HCW positivity rates did not appear to be impacted by caring for known SARS-CoV-2 infected patients suggesting that appropriate use of personal protective equipment is effective in protecting individuals from transmission.",

keywords = "COVID-19, Health systems, Personal protective equipment",

author = "Derek Forster and Nan Lin and Justin Levens and Rachael Stone and Scott Berry and Eric Durbin and Jennings, \{C. Darrell\} and Robert DiPaola and Kolesar, \{Jill M.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Association for Professionals in Infection Control and Epidemiology, Inc.",

year = "2021",

month = sep,

doi = "10.1016/j.ajic.2021.04.005",

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Forster, D, Lin, N, Levens, J, Stone, R, Berry, S , Durbin, E , Jennings, CD , DiPaola, R & Kolesar, JM 2021, 'Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk', American Journal of Infection Control, vol. 49, n.º 9, pp. 1158-1161. https://doi.org/10.1016/j.ajic.2021.04.005

TY - JOUR

T1 - Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk

AU - Forster, Derek

AU - Lin, Nan

AU - Levens, Justin

AU - Stone, Rachael

AU - Berry, Scott

AU - Durbin, Eric

AU - Jennings, C. Darrell

AU - DiPaola, Robert

AU - Kolesar, Jill M.

PY - 2021/9

Y1 - 2021/9

N2 - Background: The purpose of this study was to assess the occupational SARS-CoV-2 infection risk among health care workers (HCW) at University of Kentucky HealthCare (UKHC) by evaluating the prevalence of SARS-CoV-2 antibodies. Methods: This is a prospective cohort study of HCW at UKHC. SARS-CoV-2 IgG antibody seropositivity was measured in a CLIA-certified laboratory utilizing the Abbott Architect SARS-CoV-2 IgG antibody assay. Demographics and work type were self-reported by study participants via an emailed survey. Results: The overall antibody positivity rate of HCW was 1.55% (5/322; 95% confidence interval: 0.65%-3.71%) at cohort entry. There were no differences in antibody positivity between those that worked directly with SARS-CoV-2 infected patients and those that did not. The antibody rate of positivity of patients during the same time period was similar, 1.8% (9/499; 95% confidence interval 0.94%-3.45%). Conclusions: Antibody positivity was low and similar between HCW and patients tested during a similar time period. HCW positivity rates did not appear to be impacted by caring for known SARS-CoV-2 infected patients suggesting that appropriate use of personal protective equipment is effective in protecting individuals from transmission.

AB - Background: The purpose of this study was to assess the occupational SARS-CoV-2 infection risk among health care workers (HCW) at University of Kentucky HealthCare (UKHC) by evaluating the prevalence of SARS-CoV-2 antibodies. Methods: This is a prospective cohort study of HCW at UKHC. SARS-CoV-2 IgG antibody seropositivity was measured in a CLIA-certified laboratory utilizing the Abbott Architect SARS-CoV-2 IgG antibody assay. Demographics and work type were self-reported by study participants via an emailed survey. Results: The overall antibody positivity rate of HCW was 1.55% (5/322; 95% confidence interval: 0.65%-3.71%) at cohort entry. There were no differences in antibody positivity between those that worked directly with SARS-CoV-2 infected patients and those that did not. The antibody rate of positivity of patients during the same time period was similar, 1.8% (9/499; 95% confidence interval 0.94%-3.45%). Conclusions: Antibody positivity was low and similar between HCW and patients tested during a similar time period. HCW positivity rates did not appear to be impacted by caring for known SARS-CoV-2 infected patients suggesting that appropriate use of personal protective equipment is effective in protecting individuals from transmission.

KW - COVID-19

KW - Health systems

KW - Personal protective equipment

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UR - https://www.scopus.com/pages/publications/85113492866#tab=citedBy

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SN - 0196-6553

VL - 49

SP - 1158

EP - 1161

JO - American Journal of Infection Control

JF - American Journal of Infection Control

IS - 9

ER -

Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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