TY - JOUR
T1 - Probing inducible nitric oxide synthase with a pterin-ruthenium(II) sensitizer wire
AU - Glazer, Edith C.
AU - Le Nguyen, Yen Hoang
AU - Gray, Harry B.
AU - Goodin, David B.
PY - 2008/1/18
Y1 - 2008/1/18
N2 - (Figure Presented) Binding by the light: A photoactive ruthenium (II)-pterin wire designed to target the tetrahydrobiopterin (H4B) binding site of inducible nitric oxide synthase (iNOSheme) binds to iNOSheme in a competitive fashion with the natural cofactor and other small molecules; thus it can be used to screen potential inhibitors. Rapid charge injection to the heme occurs upon 450-nm excitation of an iNOS heme/wire conjugate.
AB - (Figure Presented) Binding by the light: A photoactive ruthenium (II)-pterin wire designed to target the tetrahydrobiopterin (H4B) binding site of inducible nitric oxide synthase (iNOSheme) binds to iNOSheme in a competitive fashion with the natural cofactor and other small molecules; thus it can be used to screen potential inhibitors. Rapid charge injection to the heme occurs upon 450-nm excitation of an iNOS heme/wire conjugate.
KW - Electron transfer
KW - Metalloenzymes
KW - Nitric oxide synthase
KW - Ruthenium
KW - Sensitizers
UR - https://www.scopus.com/pages/publications/38549093580
UR - https://www.scopus.com/pages/publications/38549093580#tab=citedBy
U2 - 10.1002/anie.200703743
DO - 10.1002/anie.200703743
M3 - Article
C2 - 18085539
AN - SCOPUS:38549093580
SN - 1433-7851
VL - 47
SP - 898
EP - 901
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 5
ER -