Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus

James D. Brien; Soila Sukupolvi-Petty; Katherine L. Williams; Chia Ying Kao Lam; Michael A. Schmid; Syd Johnson; Eva Harris; Michael S. Diamond

doi:10.1128/JVI.00327-13

Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus

James D. Brien
, Soila Sukupolvi-Petty
, Katherine L. Williams
, Chia Ying Kao Lam
, Michael A. Schmid
, Syd Johnson
, Eva Harris
, Michael S. Diamond

Producción científica: Article › revisión exhaustiva

20 Citas (Scopus)

Resumen

Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and ~ 3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus.

Idioma original	English
Páginas (desde-hasta)	7747-7753
Número de páginas	7
Publicación	Journal of Virology
Volumen	87
N.º	13
DOI	https://doi.org/10.1128/JVI.00327-13
Estado	Published - jul 2013

Financiación

Financiadores	Número del financiador
National Institute of Allergy and Infectious Diseases	U54AI065359

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.00327-13

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abstract = "Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and \textasciitilde{} 3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus.",

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AU - Brien, James D.

AU - Sukupolvi-Petty, Soila

AU - Williams, Katherine L.

AU - Lam, Chia Ying Kao

AU - Schmid, Michael A.

AU - Johnson, Syd

AU - Harris, Eva

AU - Diamond, Michael S.

PY - 2013/7

Y1 - 2013/7

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AB - Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and ~ 3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus.

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Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus

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ODS de las Naciones Unidas

ASJC Scopus subject areas

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