protection by vitamin E against endothelial cell injury by linoleic acid hydroperoxides

Bernhard Hennig; Cynthia Enoch; Ching K. Chow

doi:10.1016/S0271-5317(87)80085-4

protection by vitamin E against endothelial cell injury by linoleic acid hydroperoxides

Bernhard Hennig
, Cynthia Enoch
, Ching K. Chow

Producción científica: Article › revisión exhaustiva

39 Citas (Scopus)

Resumen

Exposure to 90 μM albumin-bound linoleic acid (18:2) for 24 hours significantly increased the rate of albumin transfer across cultured endothelial monolayers. Linoleic acid hydroperoxides (18:2-OOH) further accelerated the rate of albumin transfer over that of 18:2. Cells exposed to 18:2-OOH but not 18:2 caused a marked release of lactate dehydrogenase (LDH) into the media. Prior cellular incubation with media containing 25 μM vitamin E for 24 hours protected endothelial cells from injury by 18:2 and 18:2-OOH, as evidenced by a decreased rate of albumin transfer across the endothelium as well as reduced release of LDH into the media. These results suggest that vitamin E may provide protection against endothelial cell injury resulting from expusure to fatty acid hydroperoxides.

Idioma original	English
Páginas (desde-hasta)	1253-1259
Número de páginas	7
Publicación	Nutrition Research
Volumen	7
N.º	12
DOI	https://doi.org/10.1016/S0271-5317(87)80085-4
Estado	Published - dic 1987

Nota bibliográfica

Funding Information:
This research was supported in part by grant HL34423 from the National Heart, Lung and Blood Institute, National Institutes of Health; a grant from the American Heart Association, Kentucky Affiliate; and the University of Kentucky Agricultural Experiment Station.

Financiación

This research was supported in part by grant HL34423 from the National Heart, Lung and Blood Institute, National Institutes of Health; a grant from the American Heart Association, Kentucky Affiliate; and the University of Kentucky Agricultural Experiment Station.

Financiadores
Kentucky Affiliate
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
American Heart Association
Kentucky Agricultural Experiment Station

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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10.1016/S0271-5317(87)80085-4

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@article{516859aba0b74c9fa95a1f749a8634b5,

title = "protection by vitamin E against endothelial cell injury by linoleic acid hydroperoxides",

abstract = "Exposure to 90 μM albumin-bound linoleic acid (18:2) for 24 hours significantly increased the rate of albumin transfer across cultured endothelial monolayers. Linoleic acid hydroperoxides (18:2-OOH) further accelerated the rate of albumin transfer over that of 18:2. Cells exposed to 18:2-OOH but not 18:2 caused a marked release of lactate dehydrogenase (LDH) into the media. Prior cellular incubation with media containing 25 μM vitamin E for 24 hours protected endothelial cells from injury by 18:2 and 18:2-OOH, as evidenced by a decreased rate of albumin transfer across the endothelium as well as reduced release of LDH into the media. These results suggest that vitamin E may provide protection against endothelial cell injury resulting from expusure to fatty acid hydroperoxides.",

keywords = "endothelial cell injury, lipid peroxidation, protection, vitamin E",

author = "Bernhard Hennig and Cynthia Enoch and Chow, \{Ching K.\}",

note = "Funding Information: This research was supported in part by grant HL34423 from the National Heart, Lung and Blood Institute, National Institutes of Health; a grant from the American Heart Association, Kentucky Affiliate; and the University of Kentucky Agricultural Experiment Station.",

year = "1987",

month = dec,

doi = "10.1016/S0271-5317(87)80085-4",

language = "English",

volume = "7",

pages = "1253--1259",

number = "12",

}

TY - JOUR

T1 - protection by vitamin E against endothelial cell injury by linoleic acid hydroperoxides

AU - Hennig, Bernhard

AU - Enoch, Cynthia

AU - Chow, Ching K.

N1 - Funding Information: This research was supported in part by grant HL34423 from the National Heart, Lung and Blood Institute, National Institutes of Health; a grant from the American Heart Association, Kentucky Affiliate; and the University of Kentucky Agricultural Experiment Station.

PY - 1987/12

Y1 - 1987/12

N2 - Exposure to 90 μM albumin-bound linoleic acid (18:2) for 24 hours significantly increased the rate of albumin transfer across cultured endothelial monolayers. Linoleic acid hydroperoxides (18:2-OOH) further accelerated the rate of albumin transfer over that of 18:2. Cells exposed to 18:2-OOH but not 18:2 caused a marked release of lactate dehydrogenase (LDH) into the media. Prior cellular incubation with media containing 25 μM vitamin E for 24 hours protected endothelial cells from injury by 18:2 and 18:2-OOH, as evidenced by a decreased rate of albumin transfer across the endothelium as well as reduced release of LDH into the media. These results suggest that vitamin E may provide protection against endothelial cell injury resulting from expusure to fatty acid hydroperoxides.

AB - Exposure to 90 μM albumin-bound linoleic acid (18:2) for 24 hours significantly increased the rate of albumin transfer across cultured endothelial monolayers. Linoleic acid hydroperoxides (18:2-OOH) further accelerated the rate of albumin transfer over that of 18:2. Cells exposed to 18:2-OOH but not 18:2 caused a marked release of lactate dehydrogenase (LDH) into the media. Prior cellular incubation with media containing 25 μM vitamin E for 24 hours protected endothelial cells from injury by 18:2 and 18:2-OOH, as evidenced by a decreased rate of albumin transfer across the endothelium as well as reduced release of LDH into the media. These results suggest that vitamin E may provide protection against endothelial cell injury resulting from expusure to fatty acid hydroperoxides.

KW - endothelial cell injury

KW - lipid peroxidation

KW - protection

KW - vitamin E

UR - https://www.scopus.com/pages/publications/0023578693

UR - https://www.scopus.com/pages/publications/0023578693#tab=citedBy

U2 - 10.1016/S0271-5317(87)80085-4

DO - 10.1016/S0271-5317(87)80085-4

M3 - Article

AN - SCOPUS:0023578693

SN - 0271-5317

VL - 7

SP - 1253

EP - 1259

JO - Nutrition Research

JF - Nutrition Research

IS - 12

ER -

protection by vitamin E against endothelial cell injury by linoleic acid hydroperoxides

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

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Huella

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