TY - JOUR
T1 - Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment
T2 - A regional study
AU - Sultana, Rukhsana
AU - Reed, Tanea
AU - Perluigi, Marzia
AU - Coccia, Rafaella
AU - Pierce, William M.
AU - Butterfield, D. Allan
PY - 2007/7
Y1 - 2007/7
N2 - Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease.
AB - Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease.
KW - Hippocampus
KW - Inferior parietal lobule
KW - Mild cognitive impairment
KW - Oxidative stress
KW - Protein nitration
KW - Redox proteomics
UR - https://www.scopus.com/pages/publications/34548172399
UR - https://www.scopus.com/inward/citedby.url?scp=34548172399&partnerID=8YFLogxK
U2 - 10.1111/j.1582-4934.2007.00065.x
DO - 10.1111/j.1582-4934.2007.00065.x
M3 - Article
C2 - 17760844
AN - SCOPUS:34548172399
SN - 1582-1838
VL - 11
SP - 839
EP - 851
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
IS - 4
ER -