Rationale and Design for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

doi:10.1097/MPA.0000000000002079

Rationale and Design for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

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25 Citas (Scopus)

Resumen

Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

Idioma original	English
Páginas (desde-hasta)	568-574
Número de páginas	7
Publicación	Pancreas
Volumen	51
N.º	6
DOI	https://doi.org/10.1097/MPA.0000000000002079
Estado	Published - jul 1 2022

Nota bibliográfica

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Financiación

The study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) under award numbers U01 DK127367 (G.T., M.B.), U01 DK127377 (A.E.P., F.G.S.T., D.Y.), U01 DK127378 (C.Y.), U01 DK127382 (J.J.E., E.F., T.T.), U01 DK127384 (A.M.D., V.C., J.L.M., M.W.), U01 DK127388 (P.A.H., G.I.P., D.L.C., K.M.D., P.J.L.), U01 DK127392 (C.F.), U01 DK127395 (W.J.P.), U01 DK127400 (E.A., V.A., R.R.K., V.S., A.Z.), U01 DK127403 (J.B., M.K., S.J.P., S.S.V.), and U01 DK127404 (C.G., R.K., C.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Financiadores	Número del financiador
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK127377, U01DK127388, U01DK127400, U01DK127367, U01DK127378, U01DK127403, U01DK127404, U01DK127392, U01DK127382, U01DK127395, U01DK127384
National Center for Advancing Translational Sciences (NCATS)	KL2TR002002
Fundação para a Ciência e Tecnologia I.P.	PTDC/CCI-INF/6762/2020

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

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10.1097/MPA.0000000000002079

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title = "Rationale and Design for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium",

abstract = "Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.",

keywords = "AP - acute pancreatitis, CP - chronic pancreatitis, DCC - data coordinating center, DM - diabetes mellitus, DREAM - Diabetes RElated to Acute pancreatitis and its Mechanisms, FSIGTT - frequently sampled intravenous glucose tolerance testing, MMTT - mixed meal tolerance testing, OGTT - oral glucose tolerance testing, T1DAPC - Type 1 Diabetes in Acute Pancreatitis Consortium, autoantibody, beta cell, epidemiology, insulin, pancreatogenic diabetes, type 3c diabetes",

author = "Hart, \{Phil A.\} and Papachristou, \{Georgios I.\} and Park, \{Walter G.\} and Dyer, \{Anne Marie\} and Chinchilli, \{Vernon M.\} and Elham Afghani and Akshintala, \{Venkata S.\} and Andersen, \{Dana K.\} and Buxbaum, \{James L.\} and Conwell, \{Darwin L.\} and Dungan, \{Kathleen M.\} and Easler, \{Jeffrey J.\} and Fogel, \{Evan L.\} and Greenbaum, \{Carla J.\} and Kalyani, \{Rita R.\} and Murray Korc and Richard Kozarek and Laughlin, \{Maren R.\} and Lee, \{Peter J.\} and Maranki, \{Jennifer L.\} and Pandol, \{Stephen J.\} and Phillips, \{Anna Evans\} and Jose Serrano and Singh, \{Vikesh K.\} and Cate Speake and Temel Tirkes and Toledo, \{Frederico G.S.\} and Guru Trikudanathan and Vege, \{Santhi Swaroop\} and Ming Wang and Cemal Yazici and Atif Zaheer and Forsmark, \{Christopher E.\} and Bellin, \{Melena D.\} and Dhiraj Yadav",

year = "2022",

month = jul,

day = "1",

doi = "10.1097/MPA.0000000000002079",

language = "English",

volume = "51",

pages = "568--574",

number = "6",

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TY - JOUR

T1 - Rationale and Design for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study

T2 - A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

AU - Hart, Phil A.

AU - Papachristou, Georgios I.

AU - Park, Walter G.

AU - Dyer, Anne Marie

AU - Chinchilli, Vernon M.

AU - Afghani, Elham

AU - Akshintala, Venkata S.

AU - Andersen, Dana K.

AU - Buxbaum, James L.

AU - Conwell, Darwin L.

AU - Dungan, Kathleen M.

AU - Easler, Jeffrey J.

AU - Fogel, Evan L.

AU - Greenbaum, Carla J.

AU - Kalyani, Rita R.

AU - Korc, Murray

AU - Kozarek, Richard

AU - Laughlin, Maren R.

AU - Lee, Peter J.

AU - Maranki, Jennifer L.

AU - Pandol, Stephen J.

AU - Phillips, Anna Evans

AU - Serrano, Jose

AU - Singh, Vikesh K.

AU - Speake, Cate

AU - Tirkes, Temel

AU - Toledo, Frederico G.S.

AU - Trikudanathan, Guru

AU - Vege, Santhi Swaroop

AU - Wang, Ming

AU - Yazici, Cemal

AU - Zaheer, Atif

AU - Forsmark, Christopher E.

AU - Bellin, Melena D.

AU - Yadav, Dhiraj

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

AB - Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

KW - AP - acute pancreatitis

KW - CP - chronic pancreatitis

KW - DCC - data coordinating center

KW - DM - diabetes mellitus

KW - DREAM - Diabetes RElated to Acute pancreatitis and its Mechanisms

KW - FSIGTT - frequently sampled intravenous glucose tolerance testing

KW - MMTT - mixed meal tolerance testing

KW - OGTT - oral glucose tolerance testing

KW - T1DAPC - Type 1 Diabetes in Acute Pancreatitis Consortium

KW - autoantibody

KW - beta cell

KW - epidemiology

KW - insulin

KW - pancreatogenic diabetes

KW - type 3c diabetes

UR - https://www.scopus.com/pages/publications/85139572032

UR - https://www.scopus.com/pages/publications/85139572032#tab=citedBy

U2 - 10.1097/MPA.0000000000002079

DO - 10.1097/MPA.0000000000002079

M3 - Article

C2 - 36206460

AN - SCOPUS:85139572032

SN - 0885-3177

VL - 51

SP - 568

EP - 574

JO - Pancreas

JF - Pancreas

IS - 6

ER -

Rationale and Design for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

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