Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

Jacob S. Brenner; Daniel C. Pan; Jacob W. Myerson; Oscar A. Marcos-Contreras; Carlos H. Villa; Priyal Patel; Hugh Hekierski; Shampa Chatterjee; Jian Qin Tao; Hamideh Parhiz; Kartik Bhamidipati; Thomas G. Uhler; Elizabeth D. Hood; Raisa Yu Kiseleva; Vladimir S. Shuvaev; Tea Shuvaeva; Makan Khoshnejad; Ian Johnston; Jason V. Gregory; Joerg Lahann; Tao Wang; Edward Cantu; William M. Armstead; Samir Mitragotri; Vladimir Muzykantov

doi:10.1038/s41467-018-05079-7

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

Jacob S. Brenner
, Daniel C. Pan
, Jacob W. Myerson
, Oscar A. Marcos-Contreras
, Carlos H. Villa
, Priyal Patel
, Hugh Hekierski
, Shampa Chatterjee
, Jian Qin Tao
, Hamideh Parhiz
, Kartik Bhamidipati
, Thomas G. Uhler
, Elizabeth D. Hood
, Raisa Yu Kiseleva
, Vladimir S. Shuvaev
, Tea Shuvaeva
, Makan Khoshnejad
, Ian Johnston
, Jason V. Gregory
, Joerg Lahann

Tao Wang, Edward Cantu, William M. Armstead, Samir Mitragotri, Vladimir Muzykantov

Surgery

Producción científica: Article › revisión exhaustiva

349 Citas (Scopus)

Resumen

Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which NCs adsorbed onto the RBCs transfer from RBCs to the first organ downstream of the intravascular injection. RH improves delivery for a wide range of NCs and even viral vectors. For example, RH injected intravenously increases liposome uptake in the first downstream organ, lungs, by ~40-fold compared with free NCs. Intra-carotid artery injection of RH NCs delivers >10% of the injected NC dose to the brain, ~10× higher than that achieved with affinity moieties. Further, RH works in mice, pigs, and ex vivo human lungs without causing RBC or end-organ toxicities. Thus, RH is a clinically translatable platform technology poised to augment drug delivery in acute lung disease, stroke, and several other diseases.

Idioma original	English
Número de artículo	2684
Publicación	Nature Communications
Volumen	9
N.º	1
DOI	https://doi.org/10.1038/s41467-018-05079-7
Estado	Published - dic 1 2018

Nota bibliográfica

Publisher Copyright:
© 2018 The Author(s).

Financiación

J.S.B. was supported by NIH F32 HL 129665 – 01 and NIH K08 HL138269-01. D.C.P. was supported by NIH T32 HL07915. J.W.M. was supported by NIH T32 HL007971. N. R., R.R., and V.R.M. were supported by NIH U01EB016027. This study was supported in part by NIH via grants to V.R.M. (HL087036, HL090697, and HL121134).

Financiadores	Número del financiador
National Institutes of Health (NIH)	F32 HL 129665 – 01, HL121134, T32 HL007971, T32 HL07915, HL087036, K08 HL138269-01, U01EB016027
National Heart, Lung, and Blood Institute (NHLBI)	R01HL090697

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General
General Physics and Astronomy

Acceder al documento

10.1038/s41467-018-05079-7

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Brenner, J. S., Pan, D. C., Myerson, J. W., Marcos-Contreras, O. A., Villa, C. H., Patel, P., Hekierski, H., Chatterjee, S., Tao, J. Q., Parhiz, H., Bhamidipati, K., Uhler, T. G., Hood, E. D., Kiseleva, R. Y., Shuvaev, V. S., Shuvaeva, T., Khoshnejad, M., Johnston, I., Gregory, J. V., ... Muzykantov, V. (2018). Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude. Nature Communications, 9(1), Artículo 2684. https://doi.org/10.1038/s41467-018-05079-7

@article{d5e17d22d80e4b75b522a05fec7a151c,

title = "Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude",

abstract = "Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which NCs adsorbed onto the RBCs transfer from RBCs to the first organ downstream of the intravascular injection. RH improves delivery for a wide range of NCs and even viral vectors. For example, RH injected intravenously increases liposome uptake in the first downstream organ, lungs, by \textasciitilde{}40-fold compared with free NCs. Intra-carotid artery injection of RH NCs delivers >10\% of the injected NC dose to the brain, \textasciitilde{}10× higher than that achieved with affinity moieties. Further, RH works in mice, pigs, and ex vivo human lungs without causing RBC or end-organ toxicities. Thus, RH is a clinically translatable platform technology poised to augment drug delivery in acute lung disease, stroke, and several other diseases.",

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note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

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Brenner, JS, Pan, DC, Myerson, JW, Marcos-Contreras, OA, Villa, CH, Patel, P, Hekierski, H, Chatterjee, S, Tao, JQ, Parhiz, H, Bhamidipati, K, Uhler, TG, Hood, ED, Kiseleva, RY, Shuvaev, VS, Shuvaeva, T, Khoshnejad, M, Johnston, I, Gregory, JV, Lahann, J, Wang, T, Cantu, E, Armstead, WM, Mitragotri, S & Muzykantov, V 2018, 'Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude', Nature Communications, vol. 9, n.º 1, 2684. https://doi.org/10.1038/s41467-018-05079-7

TY - JOUR

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AU - Brenner, Jacob S.

AU - Pan, Daniel C.

AU - Myerson, Jacob W.

AU - Marcos-Contreras, Oscar A.

AU - Villa, Carlos H.

AU - Patel, Priyal

AU - Hekierski, Hugh

AU - Chatterjee, Shampa

AU - Tao, Jian Qin

AU - Parhiz, Hamideh

AU - Bhamidipati, Kartik

AU - Uhler, Thomas G.

AU - Hood, Elizabeth D.

AU - Kiseleva, Raisa Yu

AU - Shuvaev, Vladimir S.

AU - Shuvaeva, Tea

AU - Khoshnejad, Makan

AU - Johnston, Ian

AU - Gregory, Jason V.

AU - Lahann, Joerg

AU - Wang, Tao

AU - Cantu, Edward

AU - Armstead, William M.

AU - Mitragotri, Samir

AU - Muzykantov, Vladimir

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which NCs adsorbed onto the RBCs transfer from RBCs to the first organ downstream of the intravascular injection. RH improves delivery for a wide range of NCs and even viral vectors. For example, RH injected intravenously increases liposome uptake in the first downstream organ, lungs, by ~40-fold compared with free NCs. Intra-carotid artery injection of RH NCs delivers >10% of the injected NC dose to the brain, ~10× higher than that achieved with affinity moieties. Further, RH works in mice, pigs, and ex vivo human lungs without causing RBC or end-organ toxicities. Thus, RH is a clinically translatable platform technology poised to augment drug delivery in acute lung disease, stroke, and several other diseases.

AB - Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which NCs adsorbed onto the RBCs transfer from RBCs to the first organ downstream of the intravascular injection. RH improves delivery for a wide range of NCs and even viral vectors. For example, RH injected intravenously increases liposome uptake in the first downstream organ, lungs, by ~40-fold compared with free NCs. Intra-carotid artery injection of RH NCs delivers >10% of the injected NC dose to the brain, ~10× higher than that achieved with affinity moieties. Further, RH works in mice, pigs, and ex vivo human lungs without causing RBC or end-organ toxicities. Thus, RH is a clinically translatable platform technology poised to augment drug delivery in acute lung disease, stroke, and several other diseases.

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SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 2684

ER -

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

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