Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

Csaba Földy; Sang Hun Lee; Robert J. Morgan; Ivan Soltesz

doi:10.1038/nn.2609

Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

Csaba Földy
, Sang Hun Lee
, Robert J. Morgan
, Ivan Soltesz

Neuroscience

Producción científica: Article › revisión exhaustiva

76 Citas (Scopus)

Resumen

Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABA_A receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

Idioma original	English
Páginas (desde-hasta)	1047-1049
Número de páginas	3
Publicación	Nature Neuroscience
Volumen	13
N.º	9
DOI	https://doi.org/10.1038/nn.2609
Estado	Published - sept 2010

Nota bibliográfica

Funding Information:
We thank R. Zhu for excellent technical assistance, K. Ding and D. Szabadics for camera lucida reconstructions, M. Case for genotyping, J.E. Melvin for the ClC-2 knockout mouse and L. Hilgenberg, M.A. Smith, M. Cahalan, M.V. Jones, Z. Nusser and R.L. McDonald for discussions. This work was supported by US National Institutes of Health grant NS38580 (to I.S.) and the Epilepsy Foundation through the generous support of the Eric W. Lothman Training Fellowship (to S.-H.L.).

Financiación

We thank R. Zhu for excellent technical assistance, K. Ding and D. Szabadics for camera lucida reconstructions, M. Case for genotyping, J.E. Melvin for the ClC-2 knockout mouse and L. Hilgenberg, M.A. Smith, M. Cahalan, M.V. Jones, Z. Nusser and R.L. McDonald for discussions. This work was supported by US National Institutes of Health grant NS38580 (to I.S.) and the Epilepsy Foundation through the generous support of the Eric W. Lothman Training Fellowship (to S.-H.L.).

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke	R01NS038580
Epilepsy Foundation of America

ASJC Scopus subject areas

General Neuroscience

Acceder al documento

10.1038/nn.2609

Otros archivos y enlaces

Citar esto

@article{2973fb4439374621b5bd533f52121b48,

title = "Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2",

abstract = "Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.",

author = "Csaba F{\"o}ldy and Lee, \{Sang Hun\} and Morgan, \{Robert J.\} and Ivan Soltesz",

note = "Funding Information: We thank R. Zhu for excellent technical assistance, K. Ding and D. Szabadics for camera lucida reconstructions, M. Case for genotyping, J.E. Melvin for the ClC-2 knockout mouse and L. Hilgenberg, M.A. Smith, M. Cahalan, M.V. Jones, Z. Nusser and R.L. McDonald for discussions. This work was supported by US National Institutes of Health grant NS38580 (to I.S.) and the Epilepsy Foundation through the generous support of the Eric W. Lothman Training Fellowship (to S.-H.L.).",

year = "2010",

month = sep,

doi = "10.1038/nn.2609",

language = "English",

volume = "13",

pages = "1047--1049",

number = "9",

}

TY - JOUR

T1 - Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

AU - Földy, Csaba

AU - Lee, Sang Hun

AU - Morgan, Robert J.

AU - Soltesz, Ivan

N1 - Funding Information: We thank R. Zhu for excellent technical assistance, K. Ding and D. Szabadics for camera lucida reconstructions, M. Case for genotyping, J.E. Melvin for the ClC-2 knockout mouse and L. Hilgenberg, M.A. Smith, M. Cahalan, M.V. Jones, Z. Nusser and R.L. McDonald for discussions. This work was supported by US National Institutes of Health grant NS38580 (to I.S.) and the Epilepsy Foundation through the generous support of the Eric W. Lothman Training Fellowship (to S.-H.L.).

PY - 2010/9

Y1 - 2010/9

N2 - Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

AB - Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

UR - https://www.scopus.com/pages/publications/77956187511

UR - https://www.scopus.com/pages/publications/77956187511#tab=citedBy

U2 - 10.1038/nn.2609

DO - 10.1038/nn.2609

M3 - Article

C2 - 20676104

AN - SCOPUS:77956187511

SN - 1097-6256

VL - 13

SP - 1047

EP - 1049

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 9

ER -

Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto