Regulation of the cholinergic gene locus

Hiromitsu Tanaka; Masahito Shimojo; Donghai Wu; Louis B. Hersh

doi:10.1016/S0928-4257(98)80154-X

Regulation of the cholinergic gene locus

Hiromitsu Tanaka, Masahito Shimojo, Donghai Wu, Louis B. Hersh

Producción científica: Article › revisión exhaustiva

3 Citas (Scopus)

Resumen

DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.

Idioma original	English
Páginas (desde-hasta)	149-152
Número de páginas	4
Publicación	Journal of Physiology Paris
Volumen	92
N.º	2
DOI	https://doi.org/10.1016/S0928-4257(98)80154-X
Estado	Published - abr 1998

Nota bibliográfica

Funding Information:
We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.

Financiación

We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Institute on Aging	R01AG005893, AG05144

ASJC Scopus subject areas

General Neuroscience
Physiology (medical)

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title = "Regulation of the cholinergic gene locus",

abstract = "DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.",

keywords = "Choline acetyltransferase, Coordinate regulation, Protein kinase A, Transcriptional regulation, Vesicular acetylcholine transporter",

author = "Hiromitsu Tanaka and Masahito Shimojo and Donghai Wu and Hersh, \{Louis B.\}",

note = "Funding Information: We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.",

year = "1998",

month = apr,

doi = "10.1016/S0928-4257(98)80154-X",

language = "English",

volume = "92",

pages = "149--152",

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T1 - Regulation of the cholinergic gene locus

AU - Tanaka, Hiromitsu

AU - Shimojo, Masahito

AU - Wu, Donghai

AU - Hersh, Louis B.

N1 - Funding Information: We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.

PY - 1998/4

Y1 - 1998/4

N2 - DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.

AB - DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.

KW - Choline acetyltransferase

KW - Coordinate regulation

KW - Protein kinase A

KW - Transcriptional regulation

KW - Vesicular acetylcholine transporter

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U2 - 10.1016/S0928-4257(98)80154-X

DO - 10.1016/S0928-4257(98)80154-X

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SN - 0928-4257

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SP - 149

EP - 152

JO - Journal of Physiology Paris

JF - Journal of Physiology Paris

IS - 2

ER -

Regulation of the cholinergic gene locus

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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