Relaxin and matrix metalloproteinase-9 in angiotensin II-induced abdominal aortic aneurysms

Deborah A. Howatt; Maya Dajee; Xiaojie Xie; Jessica Moorleghen; Debra L. Rateri; Anju Balakrishnan; Valdeci Da Cunha; Douglas G. Johns; David E. Gutstein; Alan Daugherty; Hong Lu

doi:10.1253/circj.CJ-17-0229

Relaxin and matrix metalloproteinase-9 in angiotensin II-induced abdominal aortic aneurysms

Deborah A. Howatt
, Maya Dajee
, Xiaojie Xie
, Jessica Moorleghen
, Debra L. Rateri
, Anju Balakrishnan
, Valdeci Da Cunha
, Douglas G. Johns
, David E. Gutstein
, Alan Daugherty
, Hong Lu

Producción científica: Article › revisión exhaustiva

21 Citas (Scopus)

Resumen

Background: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). Methods and Results: Male C57BL/6 or apolipoprotein E^−/− mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E^−/− mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. Conclusions: MMP-9 deficiency augmented AngII-induced AAA.

Idioma original	English
Páginas (desde-hasta)	888-890
Número de páginas	3
Publicación	Circulation Journal
Volumen	81
N.º	6
DOI	https://doi.org/10.1253/circj.CJ-17-0229
Estado	Published - 2017

Nota bibliográfica

Publisher Copyright:
© 2017, Japanese Circulation Society. All rights reserved.

Financiación

We thank Mr. Mark Bostrom for his technical assistance with the MMP-9 genetic mouse studies and Dr. Richard Charnigo in the Department of Statistics, University of Kentucky for helping with the statistical analyses. Relaxin study was supported by an award from Merck & Co., Inc. Mmp9−/− mouse study was supported by the National Institutes of Health under award numbers R01 HL107319 and HL133723. The content of this report is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Financiadores	Número del financiador
National Institutes of Health (NIH)	HL133723, R01 HL107319
National Institutes of Health (NIH)
Merck

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-17-0229

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title = "Relaxin and matrix metalloproteinase-9 in angiotensin II-induced abdominal aortic aneurysms",

abstract = "Background: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). Methods and Results: Male C57BL/6 or apolipoprotein E−/− mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E−/− mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. Conclusions: MMP-9 deficiency augmented AngII-induced AAA.",

keywords = "Abdominal aortic aneurysm, Matrix metalloproteinase, Relaxin",

author = "Howatt, \{Deborah A.\} and Maya Dajee and Xiaojie Xie and Jessica Moorleghen and Rateri, \{Debra L.\} and Anju Balakrishnan and \{Da Cunha\}, Valdeci and Johns, \{Douglas G.\} and Gutstein, \{David E.\} and Alan Daugherty and Hong Lu",

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T1 - Relaxin and matrix metalloproteinase-9 in angiotensin II-induced abdominal aortic aneurysms

AU - Howatt, Deborah A.

AU - Dajee, Maya

AU - Xie, Xiaojie

AU - Moorleghen, Jessica

AU - Rateri, Debra L.

AU - Balakrishnan, Anju

AU - Da Cunha, Valdeci

AU - Johns, Douglas G.

AU - Gutstein, David E.

AU - Daugherty, Alan

AU - Lu, Hong

PY - 2017

Y1 - 2017

N2 - Background: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). Methods and Results: Male C57BL/6 or apolipoprotein E−/− mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E−/− mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. Conclusions: MMP-9 deficiency augmented AngII-induced AAA.

AB - Background: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). Methods and Results: Male C57BL/6 or apolipoprotein E−/− mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E−/− mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. Conclusions: MMP-9 deficiency augmented AngII-induced AAA.

KW - Abdominal aortic aneurysm

KW - Matrix metalloproteinase

KW - Relaxin

UR - https://www.scopus.com/pages/publications/85019733975

UR - https://www.scopus.com/pages/publications/85019733975#tab=citedBy

U2 - 10.1253/circj.CJ-17-0229

DO - 10.1253/circj.CJ-17-0229

M3 - Article

C2 - 28420827

AN - SCOPUS:85019733975

SN - 1346-9843

VL - 81

SP - 888

EP - 890

JO - Circulation Journal

JF - Circulation Journal

IS - 6

ER -

Relaxin and matrix metalloproteinase-9 in angiotensin II-induced abdominal aortic aneurysms

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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