Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment

Lucas S. Broster; Juan Li; Charles D. Smith; Gregory A. Jicha; Frederick A. Schmitt; Yang Jiang

doi:10.1080/13803395.2013.838942

Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment

Lucas S. Broster
, Juan Li
, Charles D. Smith
, Gregory A. Jicha
, Frederick A. Schmitt
, Yang Jiang

Producción científica: Article › revisión exhaustiva

9 Citas (Scopus)

Resumen

Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.

Idioma original	English
Páginas (desde-hasta)	946-959
Número de páginas	14
Publicación	Journal of Clinical and Experimental Neuropsychology
Volumen	35
N.º	9
DOI	https://doi.org/10.1080/13803395.2013.838942
Estado	Published - nov 1 2013

Nota bibliográfica

Funding Information:
This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.

Financiación

This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.

Financiadores	Número del financiador
National Institute of Health National Institute of Minority and Health Disparities Loan Repayment Program	P50 AG05144-21, 5 T32 AG 242-18, UL1TR000117, AG000986, 5P30AG028383
University of Kentucky Department of Behavioral Science
U.S. Department of Energy	DE-AC03-OR22725
National Center for Research Resources	UL1RR033173

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Clinical Psychology
Neurology
Clinical Neurology

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10.1080/13803395.2013.838942

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title = "Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment",

abstract = "Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.",

keywords = "Aging, Alzheimer disease, Cognitive therapy, Mild cognitive impairment, Neuropsychological tests, Repetition priming, Working memory",

author = "Broster, \{Lucas S.\} and Juan Li and Smith, \{Charles D.\} and Jicha, \{Gregory A.\} and Schmitt, \{Frederick A.\} and Yang Jiang",

note = "Funding Information: This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.",

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AU - Smith, Charles D.

AU - Jicha, Gregory A.

AU - Schmitt, Frederick A.

AU - Jiang, Yang

N1 - Funding Information: This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.

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N2 - Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.

AB - Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.

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KW - Alzheimer disease

KW - Cognitive therapy

KW - Mild cognitive impairment

KW - Neuropsychological tests

KW - Repetition priming

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Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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Huella

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