Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop

Reena Mehra; Olga A. Tjurmina; Olujimi A. Ajijola; Rishi Arora; Donald C. Bolser; Mark W. Chapleau; Peng Sheng Chen; Colleen E. Clancy; Brian P. Delisle; Michael R. Gold; Jeffrey J. Goldberger; David S. Goldstein; Beth A. Habecker; M. Louis Handoko; Robert Harvey; James P. Hummel; Thomas Hund; Christian Meyer; Susan Redline; Crystal M. Ripplinger; Marc A. Simon; Virend K. Somers; Stavros Stavrakis; Thomas Taylor-Clark; Bradley Joel Undem; Richard L. Verrier; Irving H. Zucker; George Sopko; Kalyanam Shivkumar

doi:10.1016/j.jacbts.2021.11.003

Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop

Reena Mehra
, Olga A. Tjurmina
, Olujimi A. Ajijola
, Rishi Arora
, Donald C. Bolser
, Mark W. Chapleau
, Peng Sheng Chen
, Colleen E. Clancy
, Brian P. Delisle
, Michael R. Gold
, Jeffrey J. Goldberger
, David S. Goldstein
, Beth A. Habecker
, M. Louis Handoko
, Robert Harvey
, James P. Hummel
, Thomas Hund
, Christian Meyer
, Susan Redline
, Crystal M. Ripplinger

Marc A. Simon, Virend K. Somers, Stavros Stavrakis, Thomas Taylor-Clark, Bradley Joel Undem, Richard L. Verrier, Irving H. Zucker, George Sopko, Kalyanam Shivkumar

Producción científica: Review article › revisión exhaustiva

62 Citas (Scopus)

Resumen

This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.

Idioma original	English
Páginas (desde-hasta)	265-293
Número de páginas	29
Publicación	JACC: Basic to Translational Science
Volumen	7
N.º	3
DOI	https://doi.org/10.1016/j.jacbts.2021.11.003
Estado	Published - mar 2022

Nota bibliográfica

Publisher Copyright:
© 2022 The Authors

Financiación

This workshop was supported by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institutes of Health (NIH) Office of the Director. Dr Ajijola is supported by NIH grants DP2 OD024323, OT2 OD028201, and OT2 OD023848, Dr Chen was supported by NIH grants OT2 OD028190, R01 HL139829, and the Burns & Allen Chair in Cardiology Research, Cedars-Sinai Medical Center. Dr Clancy has received research funding from NIH grants OT2 OD026580, OT2 OD026580, R01 HL152681, R01 HL128170, and U01 HL126273, InCarda Therapeutics, and the Department of Physiology and Membrane Biology Research Partnership Fund, Oracle cloud for research allocation. Dr Delisle is supported by NIH grants R01 HL153042, R01 HL141343, and the American Heart Association grant 20IPA35320141. Dr Habecker was supported by NIH grants R01 HL093056 and R01 HL146822. Dr Handoko has received an educational grant from Novartis and Boehringer Ingelheim. Dr Redline has received research funding from NIH grants R35 HL135818, R01 HL133684, U10 HD036801, R01 HL137234, R01 DK118736, R01 AG056331, and U24 HL140412, and Jazz Pharmaceuticals. Dr Ripplinger is supported in part by research funding from NIH grants OT2 OD026580, R01 HL093056, and R01 HL111600. Dr Somers is supported by NIH grants R01 HL065176 and R01 HL134885. Dr Stavrakis was supported by NIH grant R21 AG057879. Dr Taylor-Clark is supported by NIH grants R01 HL152219, U01 NS113868, OT2 OD023854, R21 DK124894, R01 DK110366, and U01 DK110366. Dr Undem is supported by NIH grant R35 HL155671. Dr Zucker has received support from Sorrento Therapeutics, Inc. and from NIH grant R01 HL126796. Dr Shivkumar is supported by NIH grants OT2 OD028201 and OT2 OD023848. Dr Ajijola is a cofounder and equity holder of NeuCures; has served as a consultant for Merck and Biosense-Webster Inc. Dr Gold has received clinical trial research funding from Boston Scientific and Medtronic; and has been a consultant for Boston Scientific, CVRx. and Medtronic. Dr Habecker is a co-inventor of a technology (intracellular sigma peptide) that Oregon Health and Science University has licensed to NervGen Pharma Corp. Dr Handoko has received research funding from Vifor Pharma; and has been a consultant for Novartis, Boehringer Ingelheim, Vifor Pharma, AstraZeneca, Bayer, MSD, Daiichi Sankyo, and Quin. Dr Hummel has been a scientific advisory board member; and holds equity in Nuvaira, Inc. Dr Redline has received consulting fees from Jazz Pharmaceuticals and Apnimed Inc. Dr Redline has received research funding from Jazz Pharmaceuticals. Dr Somers has served as a consultant for Bayer, Respicardia, Baker Tilly, and Jazz Pharmaceuticals; and has served on the scientific advisory board of the Sleep Number Corporation. Dr Shivkumar is a cofounder and equity holder of NeuCures Inc. Dr Simon is supported in part by NIH grant R01 AG058659, serves on a clinical trial steering committee for Janssen, and has consulted for Acceleron and Bial. Dr Mehra is supported by NIH grants U01HL125177, UH3HL140144 and the American Heart Association AHA 18SFRN34170013. Dr Arora is supported by NIH grants R01 HL140061, R01 HL125881, Technology Development Program, NIH Center for Accelerated Innovations at Cleveland Clinic, the American Heart Association Strategically Focused Research Networks Atrial Fibrillation Center, and has ownership interest in Rhythm Therapeutics, Inc. Dr Handoko is supported by the Dutch Heart Foundation (Senior Clinical Scientist grant 2020T058); has received research funding from Vifor Pharma; and has been a consultant for Novartis, Boehringer Ingelheim, Vifor Pharma, AstraZeneca, Bayer, MSD, Daiichi Sankyo, and Quin. The views expressed in this article are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The authors thank their colleagues Dr. Gene Civillico, Dr. Felicia Qashu, Ms. Kristina Faulk (National Institutes of Health Office of the Director), Dr. Aaron Laposky, Dr. Josh Fessel, and Dr. Michael Twery (National Heart, Lung, and Blood Institute, National Institutes of Health) for assisting with workshop agenda development and planning.

Financiadores	Número del financiador
American Heart Association Strategically Focused Research Networks Atrial Fibrillation Center
Boston Scientific and Medtronic
CVRx, Inc.
Department of Physiology and Membrane Biology Research Partnership Fund
InCarda Therapeutics
National Institutes of Health Office of Research on Women's Health
Oracle cloud	R01 HL141343, R01 HL153042
Rhythm Therapeutics, Inc.
Sorrento Therapeutics, Inc.	R01 HL126796
National Institutes of Health (NIH)	OT2 OD028190, DP2 OD024323, R01 HL139829, OT2 OD023848, OT2 OD028201
National Heart, Lung, and Blood Institute (NHLBI)
American the American Heart Association	R01 DK118736, R01 HL125881, R01 HL133684, 18SFRN34170013, R01 AG056331, R01 HL140061, U24 HL140412, U10 HD036801, 20IPA35320141, R01 HL093056, R01 HL146822, R35 HL135818, R01 HL137234
Boehringer-Ingelheim
AstraZeneca
Novartis
Medtronic
Meso Scale Diagnostics
Boston Scientific Neuromodulation Corporation
Jazz Pharmaceuticals	R01 HL134885, U01 NS113868, OT2 OD023854, R35 HL155671, U01 DK110366, R01 DK110366, R01 HL111600, R01 HL152219, R21 DK124894, R01 HL065176, R21 AG057879
Cedars-Sinai Medical Center	R01 HL152681, OT2 OD026580, U01 HL126273, R01 HL128170
Bayer Fund
Daiichi Sankyo	UH3HL140144, R01 AG058659, U01HL125177
Hartstichting	2020T058
Vifor Pharma Management

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Acceder al documento

10.1016/j.jacbts.2021.11.003

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Mehra, R., Tjurmina, O. A., Ajijola, O. A., Arora, R., Bolser, D. C., Chapleau, M. W., Chen, P. S., Clancy, C. E., Delisle, B. P., Gold, M. R., Goldberger, J. J., Goldstein, D. S., Habecker, B. A., Handoko, M. L., Harvey, R., Hummel, J. P., Hund, T., Meyer, C., Redline, S., ... Shivkumar, K. (2022). Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. JACC: Basic to Translational Science, 7(3), 265-293. https://doi.org/10.1016/j.jacbts.2021.11.003

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title = "Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop",

abstract = "This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.",

keywords = "asthma, atrial fibrillation, autonomic nervous system, cardiopulmonary, chronic obstructive pulmonary disease, circadian, heart failure, pulmonary arterial hypertension, sleep apnea, ventricular arrhythmia",

author = "Reena Mehra and Tjurmina, \{Olga A.\} and Ajijola, \{Olujimi A.\} and Rishi Arora and Bolser, \{Donald C.\} and Chapleau, \{Mark W.\} and Chen, \{Peng Sheng\} and Clancy, \{Colleen E.\} and Delisle, \{Brian P.\} and Gold, \{Michael R.\} and Goldberger, \{Jeffrey J.\} and Goldstein, \{David S.\} and Habecker, \{Beth A.\} and Handoko, \{M. Louis\} and Robert Harvey and Hummel, \{James P.\} and Thomas Hund and Christian Meyer and Susan Redline and Ripplinger, \{Crystal M.\} and Simon, \{Marc A.\} and Somers, \{Virend K.\} and Stavros Stavrakis and Thomas Taylor-Clark and Undem, \{Bradley Joel\} and Verrier, \{Richard L.\} and Zucker, \{Irving H.\} and George Sopko and Kalyanam Shivkumar",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = mar,

doi = "10.1016/j.jacbts.2021.11.003",

language = "English",

volume = "7",

pages = "265--293",

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Mehra, R, Tjurmina, OA, Ajijola, OA, Arora, R, Bolser, DC, Chapleau, MW, Chen, PS, Clancy, CE, Delisle, BP, Gold, MR, Goldberger, JJ, Goldstein, DS, Habecker, BA, Handoko, ML, Harvey, R, Hummel, JP, Hund, T, Meyer, C, Redline, S, Ripplinger, CM, Simon, MA, Somers, VK, Stavrakis, S, Taylor-Clark, T, Undem, BJ, Verrier, RL, Zucker, IH, Sopko, G & Shivkumar, K 2022, 'Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop', JACC: Basic to Translational Science, vol. 7, n.º 3, pp. 265-293. https://doi.org/10.1016/j.jacbts.2021.11.003

Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. / Mehra, Reena; Tjurmina, Olga A.; Ajijola, Olujimi A. et al.
En: JACC: Basic to Translational Science, Vol. 7, N.º 3, 03.2022, p. 265-293.

Producción científica: Review article › revisión exhaustiva

TY - JOUR

T1 - Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation

T2 - A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop

AU - Mehra, Reena

AU - Tjurmina, Olga A.

AU - Ajijola, Olujimi A.

AU - Arora, Rishi

AU - Bolser, Donald C.

AU - Chapleau, Mark W.

AU - Chen, Peng Sheng

AU - Clancy, Colleen E.

AU - Delisle, Brian P.

AU - Gold, Michael R.

AU - Goldberger, Jeffrey J.

AU - Goldstein, David S.

AU - Habecker, Beth A.

AU - Handoko, M. Louis

AU - Harvey, Robert

AU - Hummel, James P.

AU - Hund, Thomas

AU - Meyer, Christian

AU - Redline, Susan

AU - Ripplinger, Crystal M.

AU - Simon, Marc A.

AU - Somers, Virend K.

AU - Stavrakis, Stavros

AU - Taylor-Clark, Thomas

AU - Undem, Bradley Joel

AU - Verrier, Richard L.

AU - Zucker, Irving H.

AU - Sopko, George

AU - Shivkumar, Kalyanam

PY - 2022/3

Y1 - 2022/3

N2 - This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.

AB - This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.

KW - asthma

KW - atrial fibrillation

KW - autonomic nervous system

KW - cardiopulmonary

KW - chronic obstructive pulmonary disease

KW - circadian

KW - heart failure

KW - pulmonary arterial hypertension

KW - sleep apnea

KW - ventricular arrhythmia

UR - https://www.scopus.com/pages/publications/85127449194

UR - https://www.scopus.com/pages/publications/85127449194#tab=citedBy

U2 - 10.1016/j.jacbts.2021.11.003

DO - 10.1016/j.jacbts.2021.11.003

M3 - Review article

AN - SCOPUS:85127449194

SN - 2452-302X

VL - 7

SP - 265

EP - 293

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 3

ER -

Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW et al. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. JACC: Basic to Translational Science. 2022 mar;7(3):265-293. doi: 10.1016/j.jacbts.2021.11.003