Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness

Marilyn S. Campbell; Adam J. Berrones; I. M. Krishnakumar; Richard J. Charnigo; Philip M. Westgate; Bradley S. Fleenor

doi:10.1016/j.jff.2016.12.013

Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness

Marilyn S. Campbell
, Adam J. Berrones
, I. M. Krishnakumar
, Richard J. Charnigo
, Philip M. Westgate
, Bradley S. Fleenor

Producción científica: Article › revisión exhaustiva

42 Citas (Scopus)

Resumen

Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen®, would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI ⩾ 30.0 kg/m²) were randomized into placebo (n = 11, BMI = 33.18 ± 3.38 kg/m²) and curcumin (n = 11, BMI = 33.29 ± 3.69 kg/m²) supplemented groups. When CurQfen® was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 ± 0.83 m/s v. 5.84 ± 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness.

Idioma original	English
Páginas (desde-hasta)	154-160
Número de páginas	7
Publicación	Journal of Functional Foods
Volumen	29
DOI	https://doi.org/10.1016/j.jff.2016.12.013
Estado	Published - feb 1 2017

Nota bibliográfica

Publisher Copyright:
© 2016 Elsevier Ltd

Financiación

We would like to thank the staff in the CCTS for technical support with the study. We would also like to thank Drs. Mark Abel, Jody Clasey, and Travis Thomas for their insightful discussions and suggestions related to this study. This study was funded by Akay Flavours & Aromatics Pvt. Ltd., Arvle and Ellen Turner Thacker Research Fund, and was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1TR000117. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Financiadores	Número del financiador
Akay Flavours & Aromatics Pvt. Ltd.
National Institutes of Health (NIH)	UL1TR000117
National Center for Advancing Translational Sciences (NCATS)
Center for Clinical and Translational Science, University of Utah

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

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title = "Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness",

abstract = "Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen{\textregistered}, would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI ⩾ 30.0 kg/m2) were randomized into placebo (n = 11, BMI = 33.18 ± 3.38 kg/m2) and curcumin (n = 11, BMI = 33.29 ± 3.69 kg/m2) supplemented groups. When CurQfen{\textregistered} was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 ± 0.83 m/s v. 5.84 ± 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness.",

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AU - Campbell, Marilyn S.

AU - Berrones, Adam J.

AU - Krishnakumar, I. M.

AU - Charnigo, Richard J.

AU - Westgate, Philip M.

AU - Fleenor, Bradley S.

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N2 - Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen®, would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI ⩾ 30.0 kg/m2) were randomized into placebo (n = 11, BMI = 33.18 ± 3.38 kg/m2) and curcumin (n = 11, BMI = 33.29 ± 3.69 kg/m2) supplemented groups. When CurQfen® was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 ± 0.83 m/s v. 5.84 ± 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness.

AB - Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen®, would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI ⩾ 30.0 kg/m2) were randomized into placebo (n = 11, BMI = 33.18 ± 3.38 kg/m2) and curcumin (n = 11, BMI = 33.29 ± 3.69 kg/m2) supplemented groups. When CurQfen® was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 ± 0.83 m/s v. 5.84 ± 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness.

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KW - Obesity

KW - Turmeric

KW - Vascular function

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Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness

Resumen

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Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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