Riluzole improves measures of oxidative stress following traumatic spinal cord injury

Xiaojun Mu; Robert D. Azbill; Joe E. Springer

doi:10.1016/S0006-8993(00)02402-1

Riluzole improves measures of oxidative stress following traumatic spinal cord injury

Xiaojun Mu
, Robert D. Azbill
, Joe E. Springer

Producción científica: Article › revisión exhaustiva

61 Citas (Scopus)

Resumen

Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury.

Idioma original	English
Páginas (desde-hasta)	66-72
Número de páginas	7
Publicación	Brain Research
Volumen	870
N.º	1-2
DOI	https://doi.org/10.1016/S0006-8993(00)02402-1
Estado	Published - jul 7 2000

Nota bibliográfica

Funding Information:
This work was supported by grants to JES from the NIH (NS-30248 and NS40015) and the Kentucky Spinal Cord and Head Injury Research Trust (SA-9502-K3).

Financiación

This work was supported by grants to JES from the NIH (NS-30248 and NS40015) and the Kentucky Spinal Cord and Head Injury Research Trust (SA-9502-K3).

Financiadores	Número del financiador
National Institutes of Health (NIH)	NS40015
National Institutes of Health (NIH)
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council	R01NS030248
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council
Kentucky Spinal Cord and Head Injury Research Trust	SA-9502-K3
Kentucky Spinal Cord and Head Injury Research Trust

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02402-1

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title = "Riluzole improves measures of oxidative stress following traumatic spinal cord injury",

abstract = "Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury.",

keywords = "Excitotoxicity, Glucocorticoids, Glutamate release, Oxidative stress, Spinal cord trauma",

author = "Xiaojun Mu and Azbill, \{Robert D.\} and Springer, \{Joe E.\}",

note = "Funding Information: This work was supported by grants to JES from the NIH (NS-30248 and NS40015) and the Kentucky Spinal Cord and Head Injury Research Trust (SA-9502-K3).",

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AU - Mu, Xiaojun

AU - Azbill, Robert D.

AU - Springer, Joe E.

N1 - Funding Information: This work was supported by grants to JES from the NIH (NS-30248 and NS40015) and the Kentucky Spinal Cord and Head Injury Research Trust (SA-9502-K3).

PY - 2000/7/7

Y1 - 2000/7/7

N2 - Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury.

AB - Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury.

KW - Excitotoxicity

KW - Glucocorticoids

KW - Glutamate release

KW - Oxidative stress

KW - Spinal cord trauma

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Riluzole improves measures of oxidative stress following traumatic spinal cord injury

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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