Resumen
Summary: Alternative splicing generates multiple RNA isoforms from a single gene, enriching genetic diversity and impacting gene function. Effective visualization of these isoforms and their expression patterns is crucial but challenging due to limitations in existing tools. Traditional genome browsers lack programmability, while other tools offer limited customization, produce static plots, or cannot simultaneously display structures and expression levels. RNApysoforms was developed to address these gaps by providing a Python-based package that enables concurrent visualization of RNA isoform structures and expression data. Leveraging plotly and polars libraries, it offers an interactive, customizable, and faster-rendering framework suitable for web applications, enhancing the analysis and dissemination of RNA isoform research.
| Idioma original | English |
|---|---|
| Número de artículo | vbaf057 |
| Publicación | Bioinformatics Advances |
| Volumen | 5 |
| N.º | 1 |
| DOI | |
| Estado | Published - 2025 |
Nota bibliográfica
Publisher Copyright:© The Author(s) 2025. Published by Oxford University Press.
Financiación
We appreciate the contributions of the Sanders-Brown Center on Aging at the University of Kentucky. We would like to thank the University of Kentucky Center for Computational Sciences and Information Technology Services Research Computing for their support and use of the Morgan Compute Cluster and associated research computing resources. We would like to thank Singularity Sylabs for providing support and extra cloud storage for our software containers. This work was supported by the National Institutes of Health [R35GM138636, R01AG068331, RF1AG082339, P30AG072946 to M.T.W.E.]; the BrightFocus Foundation [A2020161S to M.T.W.E.]; the Alzheimer’s Association [2019-AARG44082 to M.T.W.E.]; the PhRMA Foundation [RSGTMT17 to M.T.W.E., Predoctoral Drug Discovery Fellowship to B.A.H.]; the Ed and Ethel Moore Alzheimer’s Disease Research Program of Florida Department of Health [8AZ10 and 9AZ08 to M.T.W.E.]; the Muscular Dystrophy Association [to M.T.W.E.]; and the Aligning Science Across Parkinson’s [ASAP-000478 to M.R., ASAP-000509 to E.K. G. and M.R.] through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). This work was supported by the National Institutes of Health [R35GM138636, R01AG068331, RF1AG082339, P30AG072946 to M.T.W.E.]; the BrightFocus Foundation [A2020161S to M.T.W.E.]; the Alzheimer’s Association [2019-AARG44082 to M.T.W.E.]; the PhRMA Foundation [RSGTMT17 to M.T.W.E., Predoctoral Drug Discovery Fellowship to B.A.H.]; the Ed and Ethel Moore Alzheimer’s Disease Research Program of Florida Department of Health [8AZ10 and 9AZ08 to M.T.W.E.]; the Muscular Dystrophy Association [to M.T.W.E.]; and the Aligning Science Across Parkinson’s [ASAP-000478 to M.R., ASAP-000509 to E.K.G. and M.R.] through the Michael J. Fox Foundation for Parkinson’s Research (MJFF).
| Financiadores | Número del financiador |
|---|---|
| Sanders-Brown Center on Aging | |
| University of Kentucky | |
| Muscular Dystrophy Association | |
| Kentucky Transportation Center, University of Kentucky | |
| Singularity Sylabs | |
| BrightFocus Foundation | A2020161S |
| National Institutes of Health (NIH) | RF1AG082339, R35GM138636, R01AG068331, P30AG072946 |
| Aligning Science Across Parkinson's | ASAP-000509, ASAP-000478 |
| Pharmaceutical Research and Manufacturers of America Foundation | RSGTMT17 |
| Alzheimer's Association | 2019-AARG44082 |
| Ed and Ethel Moore Alzheimer’s Disease Research Program of Florida Department of Health | 8AZ10, 9AZ08 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology
- Genetics
- Computer Science Applications
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