Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases

Preetha Shridas; Avery C. Patrick; Lisa R. Tannock

doi:10.3390/biom11121883

Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases

Preetha Shridas
, Avery C. Patrick
, Lisa R. Tannock

Producción científica: Article › revisión exhaustiva

17 Citas (Scopus)

Resumen

Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.

Idioma original	English
Número de artículo	1883
Publicación	Biomolecules
Volumen	11
N.º	12
DOI	https://doi.org/10.3390/biom11121883
Estado	Published - dic 2021

Nota bibliográfica

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Financiación

This work was supported in part by funding from the National Institutes of Health R01 HL147381 and the Department of Veterans Affairs BX004275. Author Contributions: P.S. collected the material, wrote, reviewed, edited and responsible for Author Contributions: P.S. collected the material, wrote, reviewed, edited and responsible for fund-ing acquisition; A.C.P. collected literature and responsible forconstructing the figures; L.R.T. re-viewed, edited and responsible for funding acquisition. All authors have read and agreed to the Funding:published Thisversworkion of thewas supportedmanuscript.in part by funding from the National Institutes of Health R01

Financiadores	Número del financiador
National Institutes of Health (NIH)	R01
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)	R01HL147381
National Heart, Lung, and Blood Institute (NHLBI)
U.S. Department of Veterans Affairs	BX004275
U.S. Department of Veterans Affairs

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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title = "Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases",

abstract = "Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.",

keywords = "Abdominal aortic aneurysm, Cardiovascular disease, HDL, Serum amyloid A",

author = "Preetha Shridas and Patrick, \{Avery C.\} and Tannock, \{Lisa R.\}",

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AU - Shridas, Preetha

AU - Patrick, Avery C.

AU - Tannock, Lisa R.

PY - 2021/12

Y1 - 2021/12

N2 - Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.

AB - Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.

KW - Abdominal aortic aneurysm

KW - Cardiovascular disease

KW - HDL

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Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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