Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine

Ryan L. Vander Veen; Alan T. Loynachan; Mark A. Mogler; Brandon J. Russell; D. L.Hank Harris; Kurt I. Kamrud

doi:10.1016/j.vaccine.2012.01.030

Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine

Ryan L. Vander Veen
, Alan T. Loynachan
, Mark A. Mogler
, Brandon J. Russell
, D. L.Hank Harris
, Kurt I. Kamrud

Producción científica: Article › revisión exhaustiva

62 Citas (Scopus)

Resumen

A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different animal studies. Studies done in both the intended host (pigs) and non-host (mice) species demonstrated that the RP vaccine is not shed or spread by vaccinated animals to comingled cohorts, nor does it revert to virulence following vaccination. In addition, vaccinated pigs develop both specific humoral and IFN-γ immune responses, and young pigs are protected against homologous influenza virus challenge.

Idioma original	English
Páginas (desde-hasta)	1944-1950
Número de páginas	7
Publicación	Vaccine
Volumen	30
N.º	11
DOI	https://doi.org/10.1016/j.vaccine.2012.01.030
Estado	Published - mar 2 2012

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2012.01.030

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abstract = "A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different animal studies. Studies done in both the intended host (pigs) and non-host (mice) species demonstrated that the RP vaccine is not shed or spread by vaccinated animals to comingled cohorts, nor does it revert to virulence following vaccination. In addition, vaccinated pigs develop both specific humoral and IFN-γ immune responses, and young pigs are protected against homologous influenza virus challenge.",

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AU - Vander Veen, Ryan L.

AU - Loynachan, Alan T.

AU - Mogler, Mark A.

AU - Russell, Brandon J.

AU - Harris, D. L.Hank

AU - Kamrud, Kurt I.

PY - 2012/3/2

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KW - Alphavirus replicon

KW - Hemagglutinin (HA)

KW - Safety

KW - Swine

KW - Swine influenza virus (SIV)

KW - Vaccine

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M3 - Article

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SN - 0264-410X

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SP - 1944

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JO - Vaccine

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Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine

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