TY - JOUR
T1 - Scc1 (CP0432) and Scc4 (CP0033) function as a type III secretion chaperone for CopN of Chlamydia pneumoniae
AU - Silva-Herzog, Eugenia
AU - Joseph, Sabrina S.
AU - Avery, Ann K.
AU - Coba, Jose A.
AU - Wolf, Katerina
AU - Fields, Kenneth A.
AU - Plano, Gregory V.
PY - 2011/7
Y1 - 2011/7
N2 - The Chlamydia pneumoniae CopN protein is a member of the YopN/TyeA/InvE/MxiC family of secreted proteins that function to regulate the secretion of type III secretion system (T3SS) translocator and effector proteins. In this study, the Scc1 (CP0432) and Scc4 (CP0033) proteins of C. pneumoniae AR-39 were demonstrated to function together as a type III secretion chaperone that binds to an N-terminal region of CopN. The Scc1/Scc4 chaperone promoted the efficient secretion of CopN via a heterologous T3SS, whereas, the Scc3 chaperone, which binds to a C-terminal region of CopN, reduced CopN secretion.
AB - The Chlamydia pneumoniae CopN protein is a member of the YopN/TyeA/InvE/MxiC family of secreted proteins that function to regulate the secretion of type III secretion system (T3SS) translocator and effector proteins. In this study, the Scc1 (CP0432) and Scc4 (CP0033) proteins of C. pneumoniae AR-39 were demonstrated to function together as a type III secretion chaperone that binds to an N-terminal region of CopN. The Scc1/Scc4 chaperone promoted the efficient secretion of CopN via a heterologous T3SS, whereas, the Scc3 chaperone, which binds to a C-terminal region of CopN, reduced CopN secretion.
UR - https://www.scopus.com/pages/publications/79960408159
UR - https://www.scopus.com/pages/publications/79960408159#tab=citedBy
U2 - 10.1128/JB.00203-11
DO - 10.1128/JB.00203-11
M3 - Article
C2 - 21571996
AN - SCOPUS:79960408159
SN - 0021-9193
VL - 193
SP - 3490
EP - 3496
JO - Journal of Bacteriology
JF - Journal of Bacteriology
IS - 14
ER -