Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Daiani C. Savi; Khaled A. Shaaban; Prithiba Mitra; Larissa V. Ponomareva; Jon S. Thorson; Chirlei Glienke; Jürgen Rohr

doi:10.1038/s41429-019-0154-3

Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Daiani C. Savi
, Khaled A. Shaaban
, Prithiba Mitra
, Larissa V. Ponomareva
, Jon S. Thorson
, Chirlei Glienke
, Jürgen Rohr

Producción científica: Article › revisión exhaustiva

15 Citas (Scopus)

Resumen

The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.

Idioma original	English
Páginas (desde-hasta)	306-310
Número de páginas	5
Publicación	Journal of Antibiotics
Volumen	72
N.º	5
DOI	https://doi.org/10.1038/s41429-019-0154-3
Estado	Published - may 1 2019

Nota bibliográfica

Publisher Copyright:
© 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

Financiación

Acknowledgements This work was supported by NIH grants CA 91091, GM 105977 and an Endowed University Professorship in Pharmacy to J.R. This work was also supported by National Institutes of Health grants R24 OD21479 (JST), the University of Kentucky College of Pharmacy, the University of Kentucky Markey Cancer Center and the National Center for Advancing Translational Sciences (UL1TR001998). It was also supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico–Brazil grant 424738/2016-3 and CNPq309971/2016-0 to C.G., and CAPES-Brazil – grant to D.C.S. We thank the College of Pharmacy NMR Center (University of Kentucky) for NMR support.

Financiadores	Número del financiador
CAPES Foundation, Ministry of Education of Brazil
Endowed University
University of Kentucky
National Institutes of Health (NIH)	CA 91091, GM 105977
NIH Office of the Director	R24OD021479
National Center for Advancing Translational Sciences (NCATS)	UL1TR001998
University of Kentucky Markey Comprehensive Cancer Center
Health Technology Assessment Programme
Japan Science and Technology Agency
Conselho Nacional de Desenvolvimento Científico e Tecnológico	424738/2016-3, CNPq309971/2016-0

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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title = "Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa",

abstract = "The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.",

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AU - Shaaban, Khaled A.

AU - Mitra, Prithiba

AU - Ponomareva, Larissa V.

AU - Thorson, Jon S.

AU - Glienke, Chirlei

AU - Rohr, Jürgen

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AB - The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.

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Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

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Huella

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