Semiconductor microlasers with intracavity microfluidics for biomedical analyses

Microfluidic chips have the potential to be useful in bioanalytical tools for DNA, protein, and cellular studies. To realize this potential, means for introducing fluids, separating their components, and detection must be integrated in onto the chip. Semiconductor laser microcavity spectroscopy is investigated as a means for ultrasensitive detection of various fluids, cells, and particulates. Two methods for implementing this laser device, the spectra for four different types of cells, and how the transverse mode spacings can be used to caliper the cell dimensions are discussed. The current investigations of different methods for pumping fluids through the microactivity space using mechanical or electromotive forces are also discussed.