TY - JOUR
T1 - Sequential release of multiple drugs from flexible drug delivery films
AU - Jennings, Cheryl L.
AU - Perry, Ellis K.
AU - Dziubla, Thomas D.
AU - Puleo, David A.
N1 - Publisher Copyright:
© 2017 Taylor & Francis.
PY - 2017/7/24
Y1 - 2017/7/24
N2 - Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with the increasing plasticizer content. Release profiles can be tailored by order of layers, plasticizer concentration, and drug loading, making CAP–Pluronic an appealing system for inhibiting scar tissue formation.
AB - Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with the increasing plasticizer content. Release profiles can be tailored by order of layers, plasticizer concentration, and drug loading, making CAP–Pluronic an appealing system for inhibiting scar tissue formation.
KW - Cytotoxicity
KW - drug delivery
KW - mechanical properties
KW - plasticizer
KW - sequential drug release
UR - https://www.scopus.com/pages/publications/85018426813
UR - https://www.scopus.com/inward/citedby.url?scp=85018426813&partnerID=8YFLogxK
U2 - 10.1080/00914037.2016.1252352
DO - 10.1080/00914037.2016.1252352
M3 - Article
AN - SCOPUS:85018426813
SN - 0091-4037
VL - 66
SP - 569
EP - 576
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 11
ER -