Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon

Stephen B. Milam; Thomas B. Aufdemorte; Peter J. Sheridan; Robert G. Triplett; Joseph E. Van Sickels; G. Richard Holt

doi:10.1016/0030-4220(87)90025-9

Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon

Stephen B. Milam
, Thomas B. Aufdemorte
, Peter J. Sheridan
, Robert G. Triplett
, Joseph E. Van Sickels
, G. Richard Holt

Oral Health Science

Producción científica: Article › revisión exhaustiva

90 Citas (Scopus)

Resumen

The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.

Idioma original	English
Páginas (desde-hasta)	527-532
Número de páginas	6
Publicación	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volumen	64
N.º	5
DOI	https://doi.org/10.1016/0030-4220(87)90025-9
Estado	Published - nov 1987

Nota bibliográfica

Funding Information:
This research was supported by National Institutes of Health Program Project Grant 1 PO1 NS 1963-01. *Department of Cellular and Structural Biology, University of Texas Health Science Center. *‘Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ***Department of Cellular and Structural Biology and Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ****Department of Surgery, Division of Otorhinology, University of Texas Health Science Center. *****Department of Oral and Maxillofacial Surgery, Department of Pathology, Department of Surgery, Division of Otorhino-logy, University of Texas Health Science Center.

Financiación

This research was supported by National Institutes of Health Program Project Grant 1 PO1 NS 1963-01. *Department of Cellular and Structural Biology, University of Texas Health Science Center. *‘Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ***Department of Cellular and Structural Biology and Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ****Department of Surgery, Division of Otorhinology, University of Texas Health Science Center. *****Department of Oral and Maxillofacial Surgery, Department of Pathology, Department of Surgery, Division of Otorhino-logy, University of Texas Health Science Center.

Financiadores	Número del financiador
National Institutes of Health (NIH)	1 PO1 NS 1963-01

ASJC Scopus subject areas

Pathology and Forensic Medicine
General Dentistry

Acceder al documento

10.1016/0030-4220(87)90025-9

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title = "Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon",

abstract = "The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.",

author = "Milam, \{Stephen B.\} and Aufdemorte, \{Thomas B.\} and Sheridan, \{Peter J.\} and Triplett, \{Robert G.\} and \{Van Sickels\}, \{Joseph E.\} and Holt, \{G. Richard\}",

note = "Funding Information: This research was supported by National Institutes of Health Program Project Grant 1 PO1 NS 1963-01. *Department of Cellular and Structural Biology, University of Texas Health Science Center. *{\textquoteleft}Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ***Department of Cellular and Structural Biology and Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ****Department of Surgery, Division of Otorhinology, University of Texas Health Science Center. *****Department of Oral and Maxillofacial Surgery, Department of Pathology, Department of Surgery, Division of Otorhino-logy, University of Texas Health Science Center.",

year = "1987",

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doi = "10.1016/0030-4220(87)90025-9",

language = "English",

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AU - Aufdemorte, Thomas B.

AU - Sheridan, Peter J.

AU - Triplett, Robert G.

AU - Van Sickels, Joseph E.

AU - Holt, G. Richard

N1 - Funding Information: This research was supported by National Institutes of Health Program Project Grant 1 PO1 NS 1963-01. *Department of Cellular and Structural Biology, University of Texas Health Science Center. *‘Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ***Department of Cellular and Structural Biology and Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ****Department of Surgery, Division of Otorhinology, University of Texas Health Science Center. *****Department of Oral and Maxillofacial Surgery, Department of Pathology, Department of Surgery, Division of Otorhino-logy, University of Texas Health Science Center.

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N2 - The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.

AB - The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.

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Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

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