Spinal neurons involved in the generation of at-level pain following spinal injury in the rat

Robert P. Yezierski; Chen Guang Yu; Patrick W. Mantyh; Charles J. Vierck; Douglas A. Lappi

doi:10.1016/j.neulet.2003.12.035

Spinal neurons involved in the generation of at-level pain following spinal injury in the rat

Robert P. Yezierski
, Chen Guang Yu
, Patrick W. Mantyh
, Charles J. Vierck
, Douglas A. Lappi

Neuroscience

Producción científica: Article › revisión exhaustiva

40 Citas (Scopus)

Resumen

Using a conjugate of substance P and the ribosome-inactivating protein saporin, neurons expressing the neurokinin-1 receptor in lamina I of the spinal cord were targeted to determine their role in the expression of a spontaneous pain behavior following intraspinal injections of quisqualic acid in the rat. Treatment was carried out at the time of injury in order to prevent the onset of the behavior, and following onset in order to evaluate the potential clinical utility of this intervention. Treatment at the time of injury resulted in significant decreases in onset-time and severity of pain behavior, while treatment at the time of onset led to a significant reduction of the spontaneous self-directed behavior. The results suggest that the substrate for at-level pain following spinal cord injury includes a population of spinal neurons expressing the neurokinin-1 receptor in the superficial laminae of the spinal cord.

Idioma original	English
Páginas (desde-hasta)	232-236
Número de páginas	5
Publicación	Neuroscience Letters
Volumen	361
N.º	1-3
DOI	https://doi.org/10.1016/j.neulet.2003.12.035
Estado	Published - may 6 2004

Nota bibliográfica

Funding Information:
This work was supported by NS40096 (RPY) and MH56368 (DAL). The authors thank Victoria Gority and Brandi Baker for their expert help in preparation of the manuscript.

Financiación

This work was supported by NS40096 (RPY) and MH56368 (DAL). The authors thank Victoria Gority and Brandi Baker for their expert help in preparation of the manuscript.

Financiadores	Número del financiador
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council	R01NS040096
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2003.12.035

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title = "Spinal neurons involved in the generation of at-level pain following spinal injury in the rat",

abstract = "Using a conjugate of substance P and the ribosome-inactivating protein saporin, neurons expressing the neurokinin-1 receptor in lamina I of the spinal cord were targeted to determine their role in the expression of a spontaneous pain behavior following intraspinal injections of quisqualic acid in the rat. Treatment was carried out at the time of injury in order to prevent the onset of the behavior, and following onset in order to evaluate the potential clinical utility of this intervention. Treatment at the time of injury resulted in significant decreases in onset-time and severity of pain behavior, while treatment at the time of onset led to a significant reduction of the spontaneous self-directed behavior. The results suggest that the substrate for at-level pain following spinal cord injury includes a population of spinal neurons expressing the neurokinin-1 receptor in the superficial laminae of the spinal cord.",

keywords = "Central pain, Excitotoxicity, Lamina I, Quisqualic acid, Saporin, Substance P",

author = "Yezierski, \{Robert P.\} and Yu, \{Chen Guang\} and Mantyh, \{Patrick W.\} and Vierck, \{Charles J.\} and Lappi, \{Douglas A.\}",

note = "Funding Information: This work was supported by NS40096 (RPY) and MH56368 (DAL). The authors thank Victoria Gority and Brandi Baker for their expert help in preparation of the manuscript.",

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AU - Yezierski, Robert P.

AU - Yu, Chen Guang

AU - Mantyh, Patrick W.

AU - Vierck, Charles J.

AU - Lappi, Douglas A.

N1 - Funding Information: This work was supported by NS40096 (RPY) and MH56368 (DAL). The authors thank Victoria Gority and Brandi Baker for their expert help in preparation of the manuscript.

PY - 2004/5/6

Y1 - 2004/5/6

N2 - Using a conjugate of substance P and the ribosome-inactivating protein saporin, neurons expressing the neurokinin-1 receptor in lamina I of the spinal cord were targeted to determine their role in the expression of a spontaneous pain behavior following intraspinal injections of quisqualic acid in the rat. Treatment was carried out at the time of injury in order to prevent the onset of the behavior, and following onset in order to evaluate the potential clinical utility of this intervention. Treatment at the time of injury resulted in significant decreases in onset-time and severity of pain behavior, while treatment at the time of onset led to a significant reduction of the spontaneous self-directed behavior. The results suggest that the substrate for at-level pain following spinal cord injury includes a population of spinal neurons expressing the neurokinin-1 receptor in the superficial laminae of the spinal cord.

AB - Using a conjugate of substance P and the ribosome-inactivating protein saporin, neurons expressing the neurokinin-1 receptor in lamina I of the spinal cord were targeted to determine their role in the expression of a spontaneous pain behavior following intraspinal injections of quisqualic acid in the rat. Treatment was carried out at the time of injury in order to prevent the onset of the behavior, and following onset in order to evaluate the potential clinical utility of this intervention. Treatment at the time of injury resulted in significant decreases in onset-time and severity of pain behavior, while treatment at the time of onset led to a significant reduction of the spontaneous self-directed behavior. The results suggest that the substrate for at-level pain following spinal cord injury includes a population of spinal neurons expressing the neurokinin-1 receptor in the superficial laminae of the spinal cord.

KW - Central pain

KW - Excitotoxicity

KW - Lamina I

KW - Quisqualic acid

KW - Saporin

KW - Substance P

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VL - 361

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JO - Neuroscience Letters

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ER -

Spinal neurons involved in the generation of at-level pain following spinal injury in the rat

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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