Squishing, squeezing and stretching age hematopoietic stem cells

Chih Ling Wang; Mary Mohrin

doi:10.1038/s43587-025-01044-4

Squishing, squeezing and stretching age hematopoietic stem cells

Chih Ling Wang
, Mary Mohrin

Producción científica: Comment/debate

Resumen

Two recent studies, from Shang et al. and Mejía-Ramírez et al., identify complementary mechanical mechanisms that regulate hematopoietic stem cell aging: external shear stress and internal nuclear envelope tension. These forces represent an evolutionary tradeoff between immediate immune defense and long-term stem cell maintenance.

Idioma original	English
Páginas (desde-hasta)	29-31
Número de páginas	3
Publicación	Nature Aging
Volumen	6
N.º	1
DOI	https://doi.org/10.1038/s43587-025-01044-4
Estado	Published - ene 2026

Nota bibliográfica

Publisher Copyright:
© Springer Nature America, Inc. 2026.

Financiación

Work in the Mohrin Lab is supported by a COBRE grant from NIGMS (P20GM121327), a NCI supported pilot grant from the Markey Cancer Center (MCC) and the Substance Use Priority Research Area (SUPRA), and administratively supported by NCI Cancer Center Support Grant (P30 CA177558).

Financiadores	Número del financiador
CEPR COBRE
National Childhood Cancer Registry – National Cancer Institute
National Institute of General Medical Sciences DP2GM119177 Sophie Dumont National Institute of General Medical Sciences	P20GM121327
University of Kentucky Markey Comprehensive Cancer Center	P30 CA177558

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Aging
Geriatrics and Gerontology

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10.1038/s43587-025-01044-4

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Squishing, squeezing and stretching age hematopoietic stem cells

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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