Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum

Etienne C. Hirsch; Ann M. Graybiel; Louis B. Hersh; Charles Duyckaerts; Yves Agid

doi:10.1016/0304-3940(89)90048-7

Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum

Etienne C. Hirsch, Ann M. Graybiel, Louis B. Hersh, Charles Duyckaerts, Yves Agid

Producción científica: Article › revisión exhaustiva

59 Citas (Scopus)

Resumen

Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.

Idioma original	English
Páginas (desde-hasta)	145-150
Número de páginas	6
Publicación	Neuroscience Letters
Volumen	96
N.º	2
DOI	https://doi.org/10.1016/0304-3940(89)90048-7
Estado	Published - ene 16 1989

Nota bibliográfica

Funding Information:
We thank Drs. J.J. Hauw, F. Javoy-Agid and P. Cervera for their help in the tissue preparation, Drs. G. Corkidi and J.C. Bisconte for their help in image analysis and H.F. Hall who is responsible for the photography. This work was supported by the Tourette Syndrome Association, NINCDS grant IR01 NS25529, Foundation Simone and Cino del Duca, United Parkinson's Disease Foundation, the Seaver Institute, NIH grant AG 05893 and INSERM. E.C. Hirsch is a fellow of the Fondation pour la Recherche Medicale.

Financiación

We thank Drs. J.J. Hauw, F. Javoy-Agid and P. Cervera for their help in the tissue preparation, Drs. G. Corkidi and J.C. Bisconte for their help in image analysis and H.F. Hall who is responsible for the photography. This work was supported by the Tourette Syndrome Association, NINCDS grant IR01 NS25529, Foundation Simone and Cino del Duca, United Parkinson's Disease Foundation, the Seaver Institute, NIH grant AG 05893 and INSERM. E.C. Hirsch is a fellow of the Fondation pour la Recherche Medicale.

Financiadores	Número del financiador
NINCDS	IR01 NS25529
Seaver Institute
Tourette Syndrome Association
National Institutes of Health (NIH)
American Parkinson's Disease Foundation
National Institute on Aging	R01AG005893
Fondation Simone et Cino Del Duca
Institut national de la santé et de la recherche médicale

ASJC Scopus subject areas

General Neuroscience

Acceder al documento

10.1016/0304-3940(89)90048-7

Otros archivos y enlaces

Citar esto

@article{94334b4a436247128102be063b0fc624,

title = "Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum",

abstract = "Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.",

keywords = "Acetylcholine, Choline acetyltransferase, Human, Immunocytochemistry, Striatum, Striosome",

author = "Hirsch, \{Etienne C.\} and Graybiel, \{Ann M.\} and Hersh, \{Louis B.\} and Charles Duyckaerts and Yves Agid",

note = "Funding Information: We thank Drs. J.J. Hauw, F. Javoy-Agid and P. Cervera for their help in the tissue preparation, Drs. G. Corkidi and J.C. Bisconte for their help in image analysis and H.F. Hall who is responsible for the photography. This work was supported by the Tourette Syndrome Association, NINCDS grant IR01 NS25529, Foundation Simone and Cino del Duca, United Parkinson's Disease Foundation, the Seaver Institute, NIH grant AG 05893 and INSERM. E.C. Hirsch is a fellow of the Fondation pour la Recherche Medicale.",

year = "1989",

month = jan,

day = "16",

doi = "10.1016/0304-3940(89)90048-7",

language = "English",

volume = "96",

pages = "145--150",

number = "2",

}

TY - JOUR

T1 - Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum

AU - Hirsch, Etienne C.

AU - Graybiel, Ann M.

AU - Hersh, Louis B.

AU - Duyckaerts, Charles

AU - Agid, Yves

N1 - Funding Information: We thank Drs. J.J. Hauw, F. Javoy-Agid and P. Cervera for their help in the tissue preparation, Drs. G. Corkidi and J.C. Bisconte for their help in image analysis and H.F. Hall who is responsible for the photography. This work was supported by the Tourette Syndrome Association, NINCDS grant IR01 NS25529, Foundation Simone and Cino del Duca, United Parkinson's Disease Foundation, the Seaver Institute, NIH grant AG 05893 and INSERM. E.C. Hirsch is a fellow of the Fondation pour la Recherche Medicale.

PY - 1989/1/16

Y1 - 1989/1/16

N2 - Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.

AB - Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.

KW - Acetylcholine

KW - Choline acetyltransferase

KW - Human

KW - Immunocytochemistry

KW - Striatum

KW - Striosome

UR - http://www.scopus.com/inward/record.url?scp=0024504541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024504541&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(89)90048-7

DO - 10.1016/0304-3940(89)90048-7

M3 - Article

C2 - 2522606

AN - SCOPUS:0024504541

SN - 0304-3940

VL - 96

SP - 145

EP - 150

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto