@article{4cc22ad4515046ab8d201359576a86df,
title = "Structure-Based Enzyme Engineering and Its Impact on In Vitro Glycorandomization",
abstract = "Glycoengineering: This review highlights the application of structure-based enzyme engineering toward enhancing the promiscuity of nucleotidylytransferases (such as Ep, whose active site is shown here) and glycosyltransferases, which are essential to the in vitro glycorandomization (IVG) strategy. IVG is a versatile strategy with great potential for the generation of novel therapeutics as illustrated by the preparation of a library of diversified vancomycin analogues.",
keywords = "Antibiotics, Enzyme catalysis, Glycosyl phosphate, Natural products, Transferases",
author = "Thorson, \{Jon S.\} and Barton, \{William A.\} and Dirk Hoffmeister and Christoph Albermann and Nikolov, \{Dimitar B.\}",
year = "2004",
month = jan,
day = "3",
doi = "10.1002/cbic.200300620",
language = "English",
volume = "5",
pages = "16--25",
number = "1",
}