TY - JOUR
T1 - Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII
T2 - Opportunities, limitations, and mechanistic hypotheses
AU - Borisova, Svetlana A.
AU - Zhang, Changsheng
AU - Takahashi, Haruko
AU - Zhang, Hua
AU - Wong, Alexander W.
AU - Thorson, Jon S.
AU - Liu, Hung Wen
PY - 2006/4/21
Y1 - 2006/4/21
N2 - (Chemical Equation Presented) Two's Company: DesVII, a glycosyltransferase involved in the biosynthesis of macrolide antibiotics, is unusual in that it requires an additional protein partner, DesVIII, for its full activity. The level of substrate tolerance of the DesVII/DesVIII pair was explored.
AB - (Chemical Equation Presented) Two's Company: DesVII, a glycosyltransferase involved in the biosynthesis of macrolide antibiotics, is unusual in that it requires an additional protein partner, DesVIII, for its full activity. The level of substrate tolerance of the DesVII/DesVIII pair was explored.
KW - Antibiotics
KW - Biosynthesis
KW - Carbohydrates
KW - Glycosylation
KW - Macrolides
UR - https://www.scopus.com/pages/publications/33746211329
UR - https://www.scopus.com/pages/publications/33746211329#tab=citedBy
U2 - 10.1002/anie.200503195
DO - 10.1002/anie.200503195
M3 - Article
C2 - 16538696
AN - SCOPUS:33746211329
SN - 1433-7851
VL - 45
SP - 2748
EP - 2753
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 17
ER -