SUMO and Its Role in Human Diseases

Kevin D. Sarge; Ok Kyong Park-Sarge

doi:10.1016/B978-0-12-386041-5.00004-2

SUMO and Its Role in Human Diseases

Kevin D. Sarge, Ok Kyong Park-Sarge

Producción científica: Chapter › revisión exhaustiva

72 Citas (Scopus)

Resumen

The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parkinson's diseases, as well as spinocerebellar ataxia 1 and amyotrophic lateral sclerosis. The results of two more recent studies identify two additional human disease-associated proteins that are sumoylated, amyloid precursor protein (APP), and lamin A. APP sumoylation modulates Aβ peptide levels, suggesting a potential role in Alzheimer's disease, and decreased lamin A sumoylation due to mutations near its SUMO site has been implicated in causing some forms of familial dilated cardiomyopathy.

Idioma original	English
Título de la publicación alojada	International Review of Cell and Molecular Biology
Páginas	167-183
Número de páginas	17
DOI	https://doi.org/10.1016/B978-0-12-386041-5.00004-2
Estado	Published - 2011

Serie de la publicación

Nombre	International Review of Cell and Molecular Biology
Volumen	288
ISSN (versión impresa)	1937-6448

Nota bibliográfica

Funding Information:
The authors acknowledge the support of NIH grants GM61053 and GM64606 to K. D. S., which enabled us to perform our studies cited in this review.

Financiación

The authors acknowledge the support of NIH grants GM61053 and GM64606 to K. D. S., which enabled us to perform our studies cited in this review.

Financiadores	Número del financiador
National Institutes of Health (NIH)	GM64606
National Institute of General Medical Sciences	R01GM061053

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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title = "SUMO and Its Role in Human Diseases",

abstract = "The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parkinson's diseases, as well as spinocerebellar ataxia 1 and amyotrophic lateral sclerosis. The results of two more recent studies identify two additional human disease-associated proteins that are sumoylated, amyloid precursor protein (APP), and lamin A. APP sumoylation modulates Aβ peptide levels, suggesting a potential role in Alzheimer's disease, and decreased lamin A sumoylation due to mutations near its SUMO site has been implicated in causing some forms of familial dilated cardiomyopathy.",

keywords = "ALS, APP, Alzheimer's disease, Amyotrophic lateral sclerosis, Cancer, DJ-1, Heart, Lamin, Laminopathy, Parkinson's disease, SOD1, SUMO, SUMO-1, Sumoylation, Tau, α-Synuclein",

author = "Sarge, \{Kevin D.\} and Park-Sarge, \{Ok Kyong\}",

note = "Funding Information: The authors acknowledge the support of NIH grants GM61053 and GM64606 to K. D. S., which enabled us to perform our studies cited in this review.",

year = "2011",

doi = "10.1016/B978-0-12-386041-5.00004-2",

language = "English",

series = "International Review of Cell and Molecular Biology",

pages = "167--183",

booktitle = "International Review of Cell and Molecular Biology",

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AU - Sarge, Kevin D.

AU - Park-Sarge, Ok Kyong

N1 - Funding Information: The authors acknowledge the support of NIH grants GM61053 and GM64606 to K. D. S., which enabled us to perform our studies cited in this review.

PY - 2011

Y1 - 2011

N2 - The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parkinson's diseases, as well as spinocerebellar ataxia 1 and amyotrophic lateral sclerosis. The results of two more recent studies identify two additional human disease-associated proteins that are sumoylated, amyloid precursor protein (APP), and lamin A. APP sumoylation modulates Aβ peptide levels, suggesting a potential role in Alzheimer's disease, and decreased lamin A sumoylation due to mutations near its SUMO site has been implicated in causing some forms of familial dilated cardiomyopathy.

AB - The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parkinson's diseases, as well as spinocerebellar ataxia 1 and amyotrophic lateral sclerosis. The results of two more recent studies identify two additional human disease-associated proteins that are sumoylated, amyloid precursor protein (APP), and lamin A. APP sumoylation modulates Aβ peptide levels, suggesting a potential role in Alzheimer's disease, and decreased lamin A sumoylation due to mutations near its SUMO site has been implicated in causing some forms of familial dilated cardiomyopathy.

KW - ALS

KW - APP

KW - Alzheimer's disease

KW - Amyotrophic lateral sclerosis

KW - Cancer

KW - DJ-1

KW - Heart

KW - Lamin

KW - Laminopathy

KW - Parkinson's disease

KW - SOD1

KW - SUMO

KW - SUMO-1

KW - Sumoylation

KW - Tau

KW - α-Synuclein

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M3 - Chapter

C2 - 21482412

AN - SCOPUS:79953769235

T3 - International Review of Cell and Molecular Biology

SP - 167

EP - 183

BT - International Review of Cell and Molecular Biology

ER -

SUMO and Its Role in Human Diseases

Resumen

Serie de la publicación

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

Acceder al documento

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